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A nephrogenic mechanism underlies dexmedetomidine-induced polyuria. A case report.
Rev Esp Anestesiol Reanim (Engl Ed)
April 2024
Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.
Dexmedetomidine's α-adrenoreceptor agonism has been gaining popularity in the anesthetic room as a sedative-hypnotic and analgesic agent, and with extensive perioperative use rising concern about side effects is necessary. Bradycardia and hypotension are common adverse effects, but there are also several reports of excessive urine output, possibly due to vasopressin secretion and permeability of collecting ducts. Polyuria usually resolves with discontinuation of the drug, and significant morbidity has not been reported.
View Article and Find Full Text PDFProbable Dexmedetomidine Induced Diabetes Insipidus: A Case Review.
J Pharm Pract
June 2023
Department of Pharmacy, Brigham and Women's Hospital, Boston, MA, USA.
: Despite increased use of dexmedetomidine as a light sedative in the ICU setting, diabetes insipidus (DI) secondary to a dexmedetomidine infusion has rarely been reported. : We present a 32-year-old male admitted to the surgical intensive care unit (ICU) with 50% total body surface area burn. A short time following initiation (0.
View Article and Find Full Text PDFDexmedetomidine Induced Polyuria in the Intensive Care Unit.
Case Rep Crit Care
February 2021
Division of Nephrology, Wayne State University/Detroit Medical Center, 4201 St Antoine, Detroit, MI 48201, USA.
Dexmedetomidine is an 2-adrenergic used as an adjunct therapy for sedation in the intensive care unit. While it is known to cause polyuria exclusively in perioperative conditions, not many cases are known in the intensive care unit, thus making the diagnosis challenging. We present the case of a 61-year-old male who had developed polyuria secondary to central diabetes insipidus after receiving dexmedetomidine intravenous infusion in the medical ICU.
View Article and Find Full Text PDFIntraoperative dexmedetomidine-induced polyuria from a loading dose: a case report.
J Int Med Res
April 2020
Department of Anesthesiology, HwaMei Hospital, University of Chinese Academy of Sciences (Ningbo No. 2 Hospital), Ningbo, P.R. China.
With extensive perioperative use of dexmedetomidine, there has been rising concern about its side effects, which are most commonly bradycardia and hypotension. However, increased urine output or diuresis is not well recognized with perioperative use of dexmedetomidine. We report a case of intraoperative polyuria induced by dexmedetomidine.
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