AI Article Synopsis
- Antimicrobial resistance (AMR) is a big problem in Europe, especially with certain germs like E. coli that are hard to treat.
- The study looked at whether people with kidney or stem cell transplants should be treated with antibiotics for an infection called asymptomatic bacteriuria (ASB).
- The results showed that using antibiotics didn’t help prevent infections after kidney transplants and could lead to more germs becoming resistant, so more research is needed.
Article Abstract
Background: Antimicrobial resistance (AMR), especially multidrug resistant Escherichia coli strains, is a problem even in Europe. That is why inadequate usage of antibiotic therapy should be avoided, especially in the treatment of asymptomatic bacteriuria (ASB).
Objectives: Should ASB be treated with antibiotics in immunocompromized patients, namely solid organ transplant, especially kidney transplant or stem cell transplant recipients?
Materials And Methods: A rapid review based on a systematic literature search in MEDLINE between 1980 and 2022 was performed. For evidence synthesis, only randomized controlled trials (RCTs) or quasi-RCTs were considered.
Results: No studies were identified for the search term solid organ and stem cell transplantation. Three RCTs (antibiotic therapy versus no therapy) were included for adult kidney transplantation. None of the studies showed a benefit for antibiotic therapy of ASB in reduction of symptomatic urinary tract infections, especially in the late transplantation phase two months after kidney transplantation; furthermore, this therapy may promote AMR development. In addition, there are numerous gaps of evidence, e.g., in pediatric transplantation or regarding the influence of special immunosuppressants.
Conclusion: There is no evidence for antibiotic therapy of ASB in adult kidney transplantation two months after the surgery. Further studies addressing the identified evidence gaps are essential for the prevention of further AMR development.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244293 | PMC |
| http://dx.doi.org/10.1007/s00120-023-02059-8 | DOI Listing |
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