Inferring danger with minimal aversive experience.

Learning about threats is crucial for survival and fundamentally rests upon Pavlovian conditioning. However, Pavlovian threat learning is largely limited to detecting known (or similar) threats and involves first-hand exposure to danger, which inevitably poses a risk of harm. We discuss how individuals leverage a rich repertoire of mnemonic processes that operate largely in safety and significantly expand our ability to recognize danger beyond Pavlovian threat associations. These processes result in complementary memories - acquired individually or through social interactions - that represent potential threats and the relational structure of our environment. The interplay between these memories allows danger to be inferred rather than directly learned, thereby flexibly protecting us from potential harm in novel situations despite minimal prior aversive experience.