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| http://dx.doi.org/10.1016/j.wneu.2023.03.069 | DOI Listing |
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A new vision of the role of the cerebellum in pain processing.
J Neural Transm (Vienna)
January 2025
Postgraduate Program in Physical Therapy (PPGFT), Department of Physical Therapy (DFisio), University of São Carlos (UFSCar), Washington Luis Road, Km 235, São Carlos, São Paulo, 13565-905, Brazil.
The cerebellum is a structure in the suprasegmental nervous system classically known for its involvement in motor functions such as motor planning, coordination, and motor learning. However, with scientific advances, other functions of the cerebellum, such as cognitive, emotional, and autonomic processing, have been discovered. Currently, there is a body of evidence demonstrating the involvement of the cerebellum in nociception and pain processing.
View Article and Find Full Text PDFLong-term effects of linear versus macrocyclic GBCAs on gene expression in the central nervous system of mice.
Eur Radiol Exp
January 2025
Laboratory of Molecular Imaging, Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Background: We examined chronic gadolinium retention impact on gene expression in the mouse central nervous system (CNS) after injection of linear or macrocyclic gadolinium-based contrast agents (GBCAs).
Methods: From 05/2022 to 07/2023, 36 female mice underwent weekly intraperitoneal injections of gadodiamide (2.5 mmol/kg, linear), gadobutrol (2.
Brain magnetic resonance imaging findings in Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE): A case-based review.
Radiol Case Rep
March 2025
Department of Radiology, Medical School, University of Ioannina, Stavros Niarchos Avenue, Ioannina 45500, Greece.
Mitochondrial neurogastrointestinal encephalopathy (MNGIE) is a rare autosomal recessive disorder, manifesting with gastrointestinal dysmotility, cachexia, ptosis and peripheral neuropathy. Diffuse leukoencephalopathy in brain MRI is a hallmark of MNGIE. We report a case of a 21-year-old female with MNGIE, presenting with cachexia and chronic diarrhea.
View Article and Find Full Text PDFQuantitative evaluation of dynamic glymphatic activity in insomnia: A contrast-enhanced synthetic MRI study.
Sleep Med
January 2025
Department of Radiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University Nanchang, 330006, China; Intelligent Medical Imaging of Jiangxi Key Laboratory, 330006, Nanchang, China; School of Biomedical Engineering, National Graduate College for Engineers, Tsinghua University, 100084, Beijing, China. Electronic address:
Article Synopsis
- The study investigates the connection between insomnia disorder (ID) and glymphatic circulation, utilizing dynamic synthetic magnetic resonance imaging (syMRI) on 32 insomnia patients and 10 healthy volunteers.
- Results showed significant differences in T1 signal values in several brain areas, including the insula gray matter and hippocampal gray matter, between insomnia patients and the control group at various time points.
- Statistical analyses indicated that time-varying T1 values in cerebral gray matter and the putamen also differed significantly between groups, suggesting potential glymphatic system involvement in insomnia.
Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors.
Nat Neurosci
January 2025
Department of Physiology, Seoul National University College of Medicine, Seoul, Korea.
The cerebellum is activated by noxious stimuli and pathological pain but its role in noxious information processing remains unknown. Here, we show that in mice, cutaneous noxious electrical stimuli induced noradrenaline (NA) release from locus coeruleus (LC) terminals in the cerebellar cortex. Bergmann glia (BG) accumulated these LC-NA signals by increasing intracellular calcium in an integrative manner ('flares').
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