AI Article Synopsis
- Automated synthesis of Ga-based tracers allows for in-house production of [Ga]Ga-oxine-labeled erythrocytes, which aids in imaging patients with splenic disorders.
- The method involves producing [Ga]Ga-oxine using an automated synthesizer in a GMP-certified lab, including a successful PET/CT imaging case for identifying an intrapancreatic mass.
- Results indicate that the labeled erythrocytes meet quality standards and effectively differentiate between splenic tissue and tumors, establishing a standard operating procedure for clinical use.
Article Abstract
Introduction: With the introduction of automated synthetization methods, the in-house production of several Ga-based tracers became feasible in hospital laboratories. We describe a possible standard operating procedure (SOP) for [Ga]Ga-oxine-labeled heat-denaturated erythrocytes, which can be used for selective imaging in patients with splenic disorders.
Methods: Heat-denaturated erythrocytes were labeled with [Ga]Ga-oxine, which was produced from Ga and 8-hydroxyquinoline on an automated synthesizer. The workflow was validated in a good manufacturing/good radiopharmaceutical practice (GMP/GRP) certified laboratory. A patient underwent [Ga]Ga-oxine-erythrocyte PET/CT for differentiation of an intrapancreatic mass.
Results: [Ga]Ga-oxine and [Ga]Ga-oxine-labeled erythrocytes could be synthesized reproducibly and reliably. The products met GMP quality standards. The tracer showed high accumulation in the intrapancreatic mass, consistent with an accessory spleen.
Conclusions: PET/CT imaging with [Ga]Ga-oxine-labeled, heat-denaturated erythrocytes can be a backup method for the differentiation of functioning splenic tissue from tumors. An SOP for the production of the tracer in a clinical setting could be established.
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| http://dx.doi.org/10.1016/j.nucmedbio.2023.108333 | DOI Listing |
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Article Synopsis
- Automated synthesis of Ga-based tracers allows for in-house production of [Ga]Ga-oxine-labeled erythrocytes, which aids in imaging patients with splenic disorders.
- The method involves producing [Ga]Ga-oxine using an automated synthesizer in a GMP-certified lab, including a successful PET/CT imaging case for identifying an intrapancreatic mass.
- Results indicate that the labeled erythrocytes meet quality standards and effectively differentiate between splenic tissue and tumors, establishing a standard operating procedure for clinical use.
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