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Clinicopathologic and Molecular Characterization of Basal Cell Carcinoma Arising at Sun-protected Sites.
Am J Surg Pathol
January 2025
Department of Pathology, Brigham and Women's Hospital.
Basal cell carcinomas (BCC) are driven primarily by cumulative ultraviolet (UV) radiation exposure resulting in activation of the Hedgehog (Hh) signaling pathway, often as a result of UV-mediated Patched-1 (PTCH1) gene inactivation. Accordingly, BCCs most commonly arise at sun-exposed sites such as the head and neck. Very rarely, BCCs can arise at sun-protected sites such as the genital skin and perianal area.
View Article and Find Full Text PDFPigmented basal cell carcinoma of the anus: a rare entity with diagnostic challenges.
J Surg Case Rep
August 2024
Department of Colon and Rectal Surgery, Hospital Médica Sur, Mexico City, Mexico.
Anal cancer is uncommon, comprising 2.2% of gastrointestinal cancers. Squamous cell carcinoma (SCC) is the most common; while perianal basal cell carcinoma (BCC) is rare, representing only 0.
View Article and Find Full Text PDFPerianal Basal Cell Carcinoma: A Diagnostic Challenge.
Dermatol Pract Concept
July 2024
Department of Dermatology, University of Barcelona, Hospital Clinic of Barcelona, Barcelona, Spain.
Basal cell carcinoma at an eccentric location: A rare case report.
Indian J Sex Transm Dis AIDS
June 2024
Department of Dermatology, Command Hospital Airforce, Bengaluru, Karnataka, India.
Basal cell carcinoma (BCC) is the most common form of skin cancer, which presents with local invasion, has low metastasizing potential and a cure rate of 100% after surgical excision. BCC commonly involves sun-exposed areas with approximately 80%-85% of BCC located on the head or neck, 15% on the trunk, and <2% in unusual areas such as the abdomen, genitals, perianal skin, lateral edge of the foot, axilla, superior or inferior lip.
View Article and Find Full Text PDFShining Light on a Dark Corner: A Case Report on Perianal Basal Cell Carcinoma.
Cureus
May 2024
Department of Radiation Oncology, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, MAR.
Perianal basal cell carcinoma (BCC) is a rare occurrence, with limited documented cases in the existing literature. The precise etiology contributing to its onset remains inadequately elucidated. Macroscopically, perianal BCC often exhibits atypical features, potentially leading to diagnostic challenges.
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