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Eruption of Generalized Pustular Psoriasis Following Initiation of Adalimumab for Hidradenitis Suppurativa: A Case Report.
Cureus
December 2024
Dermatology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA.
Rarely, tumor necrosis factor (TNF)-α inhibitors can paradoxically induce eruptions of psoriasis with generalized pustular psoriasis being among the least common presentations. We report a patient who presented with a generalized pustular eruption following adalimumab therapy for hidradenitis suppurativa (HS). The diagnosis of generalized pustular psoriasis was confirmed with a biopsy showing neutrophilic spongiosis and intraepidermal pustulosis.
View Article and Find Full Text PDFHidradenitis suppurativa pathogenesis: Extrinsic factors.
J Am Acad Dermatol
December 2024
Department of Dermatology, University of California, San Francisco, San Francisco, California. Electronic address:
While genetic predisposition and immune dysregulation are recognized as key contributors to the development of hidradenitis suppurativa, accumulating research points to the influence of extrinsic factors in the pathogenesis of this condition. This review explores the roles of mechanical stress, altered skin and gut microbiome, tobacco smoking, diet, and paradoxical drug reactions as drivers of hidradenitis suppurativa onset and progression. A holistic management approach addressing these factors may be encouraged to improve disease outcomes.
View Article and Find Full Text PDFPyoderma gangrenosum during infliximab in severe hidradenitis suppurativa: A paradoxical event.
Australas J Dermatol
December 2024
Dermatologic Clinic, Department of Medical Science, University of Turin, Turin, Italy.
Case report: Psoriasiform eczema with immune-mediated comorbidities treated with upadacitinib.
Front Immunol
August 2024
Department of Dermatology, Dipartimento di scienze della salute - DISSAL, University of Genoa, Genova, Italy.
Immune-mediated comorbidities in patients with psoriasiform eczema are common. It can be challenging to manage multiple immune-mediated diseases, especially considering that biologic treatments are prone to causing paradoxical effects. The aim of this retrospective observational case series was to describe the course of both psoriasiform eczema and immune-mediated comorbidities in five patients treated with upadacitinib for psoriasiform dermatitis.
View Article and Find Full Text PDFBehcet's-like disease induced by secukinumab in a patient with psoriasis: a case report and literature review.
J Dermatolog Treat
December 2024
Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China.
The incidence of cutaneous paradoxical reactions associated with IL-17 inhibitors has gained attention in recent literature. Our report aims to investigate the characteristics of one rare paradoxical reaction, presenting as Behcet's disease. We reported one case of Behcet's-like disease induced by secukinumab in a patient with psoriasis.
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