We propose a censored quantile regression model for the analysis of relative survival data. We create a hybrid data set consisting of the study observations and counterpart randomly sampled pseudopopulation observations imputed from population life tables that adjust for expected mortality. We then fit a censored quantile regression model to the hybrid data incorporating demographic variables (e.g., age, biologic sex, calendar time) corresponding to the population life tables of demographically-similar individuals, a population versus study covariate, and its interactions with the variables of interest. These latter variables can be interpreted as relative survival parameters that depict the differences in failure quantiles between the study participants and their population counterparts.
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http://dx.doi.org/10.1002/bimj.202200127 | DOI Listing |
Toxics
December 2024
Nantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China.
Background: Brominated flame retardants (BFRs) are a type of widespread pollutant that can be transmitted through particulate matter, such as dust in the air, and have been associated with various adverse health effects, such as diabetes, metabolic syndrome, and cardiovascular disease. However, there is limited research on the link between exposure to mixtures of BFRs and depression in the general population.
Methods: To analyze the association between exposure to BFRs and depression in the population, nationally representative data from the National Health and Nutrition Examination Survey (NHANES; 2005-2016) were used.
Toxics
December 2024
Department of Built Environment, North Carolina A&T State University, Greensboro, NC 27411, USA.
This study investigates the combined effects of environmental pollutants (lead, cadmium, total mercury) and behavioral factors (alcohol consumption, smoking) on depressive symptoms in women. Data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 cycle, specifically exposure levels of heavy metals in blood samples, were used in this study. The analysis of these data included the application of descriptive statistics, linear regression, and Bayesian Kernel Machine Regression (BKMR) to explore associations between environmental exposures, behavioral factors, and depression.
View Article and Find Full Text PDFToxics
November 2024
Medical School, Southeast University, Nanjing 210096, China.
: Limited evidence links urinary metal exposure to osteoporosis in broad populations, prompting this study to cover this knowledge gap using supervised and unsupervised approaches. : This study included 15,923 participants from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2020. Urinary concentrations of nine metals-barium (Ba), cadmium (Cd), cobalt (Co), cesium (Cs), molybdenum (Mo), lead (Pb), antimony (Sb), thallium (Tl), and tungsten (Tu)-were measured using inductively coupled plasma mass spectrometry (ICP-MS).
View Article and Find Full Text PDFToxics
November 2024
Nantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China.
Emerging studies demonstrate that exposure to brominated flame retardants (BFRs) can have harmful effects on human health. Our study focused on the relationship between exposure to various BFRs and markers of liver function. To further explore the association between BFR exposure and liver function impairment, we used data from the National Health and Nutrition Examination Surveys (NHANES) for three cycles from 2009 to 2014, leaving 4206 participants (≥20 years of age) after screening.
View Article and Find Full Text PDFEntropy (Basel)
December 2024
Volgenau School of Engineering, George Mason University, 4400 University Drive, MSN 5D3, Fairfax, VA 22030, USA.
Generative Bayesian Computation (GBC) methods are developed to provide an efficient computational solution for maximum expected utility (MEU). We propose a density-free generative method based on quantiles that naturally calculates expected utility as a marginal of posterior quantiles. Our approach uses a deep quantile neural estimator to directly simulate distributional utilities.
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