AI Article Synopsis
- Nature's natural biosynthetic pathways create complex molecules far better than chemical methods, but they're limited in flexibility.
- This study introduces non-natural biocatalytic modules to enhance traditional synthesis with new enzymatic reactions, like a peroxidase-mediated rearrangement and a dehydrogenase-catalyzed isomerization.
- The researchers successfully synthesized tricyclic angiopterlactone B in just two steps using primarily enzymes in a water-based system, showcasing a blend of traditional and biosynthetic approaches.
Article Abstract
Nature's way to construct highly complex molecular entities as part of biosynthetic pathways is unmatched by any chemical synthesis. Yet, relying on a cascade of native enzymatic transformations to achieve a certain target structure, biosynthesis is also significantly limited in its scope. In this study, non-natural biocatalytic modules, a peroxidase-mediated Achmatowicz rearrangement and a dehydrogenase-catalyzed borrowing-hydrogen-type isomerization were successfully incorporated into an artificial metabolism, combining the benefits of traditional retrosynthesis with the elegance and efficacy of biosynthetic networks. In a highly streamlined process, the total synthesis of tricyclic angiopterlactone B was achieved in two steps operating entirely in an aqueous environment while relying mainly on enzymes as key reaction mediators.
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| http://dx.doi.org/10.1002/anie.202301178 | DOI Listing |
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