AI Article Synopsis
- Migraines are a significant neurological disorder that impact both health and economy, highlighting the need for better understanding of their underlying mechanisms.
- Research using resting-state functional MRI has shown abnormal connectivity in the default mode network of migraine patients, suggesting potential biomarkers for the condition, though findings have been inconsistent.
- A meta-analysis of nine studies with 204 migraine patients and 199 healthy subjects revealed specific areas of increased and decreased connectivity in migraine sufferers, offering new insights for more effective treatments.
Article Abstract
Migraine-a disabling neurological disorder, imposes a tremendous burden on societies. To reduce the economic and health toll of the disease, insight into its pathophysiological mechanism is key to improving treatment and prevention. Resting-state functional magnetic resonance imaging (rs-fMRI) studies suggest abnormal functional connectivity (FC) within the default mode network (DMN) in migraine patients. This implies that DMN connectivity change may represent a biomarker for migraine. However, the FC abnormalities appear inconsistent which hinders our understanding of the potential neuropathology. Therefore, we performed a meta-analysis of the FC within the DMN in migraine patients in the resting state to identify the common FC abnormalities. With efficient search and selection strategies, nine studies (published before July, 2022) were retrieved, containing 204 migraine patients and 199 healthy subjects. We meta-analyzed the data using the Anisotropic Effect Size version of Signed Differential Mapping (AES-SDM) method. Compared with healthy subjects, migraine patients showed increased connectivity in the right calcarine gyrus, left inferior occipital gyrus, left postcentral gyrus, right cerebellum, right parahippocampal gyrus, and right posterior cingulate gyrus, while decreased connectivity in the right postcentral gyrus, left superior frontal gyrus, right superior occipital gyrus, right orbital inferior frontal gyrus, left middle occipital gyrus, left middle frontal gyrus and left inferior frontal gyrus. These results provide a new perspective for the study of the pathophysiology of migraine and facilitate a more targeted treatment of migraine in the future.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014826 | PMC |
| http://dx.doi.org/10.3389/fnins.2023.1136790 | DOI Listing |
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