AI Article Synopsis
- The effectiveness of oral specimen nucleic acid amplification tests (NAATs) for diagnosing pulmonary tuberculosis (PTB) is debated, prompting a systematic review of their diagnostic performance.
- An analysis of 23 studies showed that NAATs in oral samples have a sensitivity of 50% and a high specificity of 97%, indicating they are better at ruling out PTB than detecting it.
- The review highlighted significant variability in the results, suggesting that factors like age may influence outcomes, so the findings should be interpreted carefully.
Article Abstract
The diagnostic accuracy of oral specimen nucleic acid amplification tests (NAATs) for pulmonary tuberculosis (PTB) remains controversial. We performed a systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, including studies that reported the diagnostic yield of NAATs in oral samples for PTB diagnosis. The pooled estimates, including those of sensitivity and specificity, were calculated, and a meta-regression was performed to investigate heterogeneity, which was determined using χ and ² tests. A total of 23 articles were included, and the pooled sensitivity, specificity, and area under the curve of NAATs in oral samples for PTB diagnosis were 50% (95% CI, 37%-63%), 97% (95% CI, 93%-99%), and 0.89 (95% CI, 86%-92%; = 99%; chi-square, 169.61; < .001), respectively. Our data demonstrated that NAATs using oral samples have a less satisfactory sensitivity and high specificity for PTB diagnosis. However, due to significant heterogeneity, such as heterogeneity in age, the results should be interpreted with caution.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019807 | PMC |
| http://dx.doi.org/10.1093/ofid/ofad082 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparison of original and new South African formulae for age estimation in African Black and white children and adolescents using dental and hand-wrist methods.
Int J Legal Med
December 2024
AgEstimation Project, Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Campobasso, Italy.
Background: Methods for age estimation in children involve measurements of: (1) the projections of open apices and tooth heights (T), (2) the total area of the carpal bones and the epiphyses of the ulna and radius (HW), and (3) a combination of these parameters (THW). This study aimed to compare the accuracy of the original formulae for T, HW, and THW in Black South African (BSA) and White South African (WSA) samples of children and adolescents.
Materials And Methods: The sample comprised 556 subjects, 164 BSA (71 males and 93 females) and 392 WSA (171 males and 221 females) aged 6 to 16 years.
Breath Analyzer for Real-Time Exercise Fat Burning Prediction: Oral and Alveolar Breath Insights with CNN.
ACS Sens
December 2024
Electronics and Telecommunications Research Institute (ETRI), Daejeon 34129, Republic of Korea.
The increasing prevalence of obesity and metabolic disorders has created a significant demand for personalized devices that can effectively monitor fat metabolism. In this study, we developed an advanced breath analyzer system designed to provide real-time monitoring of exercise-induced fat burning by analyzing volatile organic compounds (VOCs) present in both oral and alveolar breath. Acetone in exhaled breath and β-hydroxybutyric acid (BOHB) in the blood are both biomarkers closely linked to the metabolic fat burning process occurring in the liver, particularly after exercise.
View Article and Find Full Text PDFComparison of positive BioFire FilmArray meningitis/encephalitis (ME) panels, CSF cultures, CSF parameters, clinical presentation and in-patient mortality among patients with bacterial and fungal meningitis.
Microbiol Spectr
December 2024
Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky, USA.
Unlabelled: The BioFire FilmArray meningitis/encephalitis panel (MEP) was brought to the University of Kentucky in 2016 to aid in the identification of community-acquired meningitis and encephalitis (ME). This panel has shown variable performance with some institutions showing high sensitivity and specificity for many pathogens but others seeing false positives during clinical use. We evaluated the panel's performance using retrospective chart review of patients at the University of Kentucky from October 2016 to September 2022, including 7,551 MEP results.
View Article and Find Full Text PDFA flavoromics approach to investigate the effect of Saskatoon berry powder on the sensory attributes, acceptability, volatile components, and electronic nose responses of a low-fat frozen yogurt.
Front Nutr
December 2024
Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada.
Introduction: Saskatoon berries are grown in Canada and some northwestern states in the United States, and are notable for containing abundant antioxidant polyphenols, vitamins, metal elements, and fiber. To increase consumer interest in and accessibility to Saskatoon berries, some producers have begun to develop processes for refining Saskatoon berries into a powder with an extended shelf life that can be incorporated into a variety of value-added food products. To assess the desirability of this approach, this study sought to determine how the sensory attributes, consumer acceptability, and volatile and non-volatile composition of a plain, Greek-style frozen yogurt (PY) changed when fortified with 16% Saskatoon berry powder (SBP).
View Article and Find Full Text PDFPharmacokinetics and metabolism of ketoconazole after single ocular instillation in Sprague-Dawley rats.
ADMET DMPK
November 2024
Bioduro-Sundia, Shanghai, China.
Background And Purpose: Ketoconazole is limited to its conditioned oral use due to hepatic toxicity. Its ocular eye drop administration may be an option for mycotic keratitis treatment. Therefore, it is necessary to explore its pharmacokinetic and metabolic profile via topical ocular administration.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!