AI Article Synopsis
- The study examined how gold nanoparticles (AuNPs) facilitate the reduction of dioxygen using two electron donors, sodium ascorbate and hydroethidine, while also investigating the formation of reactive oxygen species (ROS) like O˙ and HO.
- The findings indicate that ROS produced during this process are only temporary intermediates on the AuNP surfaces and are quickly converted to water, suggesting that reports of excessive ROS production in the presence of AuNPs may be overstated.
- The research proposes that when assessing cellular damage linked to AuNPs, it's essential to consider their role in catalyzing redox reactions that can lead to oxidative stress by oxidizing antioxidants in the cell.
Article Abstract
In this work, the mechanism of dioxygen reduction catalysed by gold nanoparticles (AuNPs) by two electron donors was investigated, , by sodium ascorbate and hydroethidine, focusing on potential ROS (reactive oxygen species) formation, such as O˙ and HO. According to our results, when AuNPs catalyse the reduction of O, ROS are formed only as intermediates on the surface of nanoparticles, and they are unavoidably reduced to water, catalysed by the AuNPs. Thus, the statement on ROS production in the presence of AuNPs often reported in the literature is excessive. The AuNPs can catalyze the oxidation of electron donors in the cell, , antioxidants causing oxidative stress. Therefore we propose that when explaining damage in the living cells observed in the presence of AuNP, the catalysis of redox reactions by AuNPs must be considered.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015436 | PMC |
| http://dx.doi.org/10.1039/d3ra00443k | DOI Listing |
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