Marie Jahoda's latent deprivation model proposes that unemployed people have a worse mental health compared to employed people. This is because they suffer not only from a lack of the manifest function of employment (earning money), but also from a lack of five so-called latent functions of employment: Time structure, social contact, collective purpose (i.e., the sense of being useful to other people), status, and activity. In order to test the basic assumptions of this theory, a study based on meta-analytic methods was conducted. Results showed that employed people reported higher levels on all five latent functions, as well as on the manifest function, compared to unemployed people. They also report more latent functions than people who are out of the labor force (OLF). Moreover, OLF-people reported more manifest and latent functions than unemployed people. Specific analyses for three OLF-subgroups found retired people to be almost as deprived of the latent functions (but not the manifest function) as unemployed people, while students were more similar to employed people but still experienced some manifest and latent deprivation. For homemakers, the effect sizes pointed in the expected direction, but they were not significant. Thus, the proposition that employment is the best provider of the latent functions was generally endorsed, although homemakers need further scrutiny in future studies. All latent functions, as well as the manifest function, emerged as significant independent predictors of mental health, when the influence of the other manifest and latent functions was controlled. Together, the dimensions in the model explained 19% of variation in mental health.
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http://dx.doi.org/10.3389/fpsyg.2023.1017358 | DOI Listing |
Alzheimers Dement
December 2024
Allen Institute for Brain Science, Seattle, WA, USA.
Background: Alzheimer's Disease is marked by the gradual aggregation of pathological proteins, Tau and beta-amyloid, throughout various areas of the brain. The progression of these pathologies follows a consistent pattern, impacting various cellular populations as it advances through each brain region. Previously, we used Bayesian algorithms to create a continuous progression score to mathematically capture the collective aggregation of multiple pathological variables within a specific brain region.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Background: The infectious hypothesis of Alzheimer's disease (AD) suggests that microbes may play a role in pathogenesis by triggering the pathologic cascade or contributing to disease progression. Herpesviruses, such as Epstein-Barr virus (EBV), have been of high interest in AD and related neurodegenerative diseases, in part due to their ability to establish lifelong latent infection and potentially reactivate. However, further research is needed to fully understand the role of herpesviruses in these diseases.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Massachusetts Chan Medical School, Worcester, MA, USA.
Background: Several studies have found that oral and gut microbiome and their byproducts can impact Alzheimer's Disease (AD). The objective of our study is to analyze metagenomic sequencing data from paired oral and fecal microbiomes, along with clinical variables, to identify communities of bacteria associated with AD. This research aims to improve our understanding of the microbiome community matrix, and how these communities interact and correlate with AD status compared to healthy controls (HC) through an oral-gut microbial axis.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Laboratory of Cellular Neurobiology, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Background: In Alzheimer's disease (AD) the fact that neuropsychiatric symptoms can predate the onset of cognitive symptoms suggests that greater focus on the non-cognitive behavioral changes in earlier life could be an opportunity to investigate 'latent' mild behavioral impairment (MBI) as a possible diagnostic strategy for preclinical AD.
Method: We used 1- and 6-month-old 3xTg-AD male mice and age-matched wild-type animals (CEUA-ICB/USP: 127/2015). Two batteries of behavioral tests were performed: (1) open field test (OFT), novel object recognition test (NORT), and rotarod test; (2) elevated zero maze test (EZMT), forced swim test (FST), and sucrose preference test (SPT).
Alzheimers Dement
December 2024
College of Public Health, University of Kentucky, Lexington, KY, USA.
Background: We recently reported genetic associations with dementia-related proteinopathies. Using multidimensional generalized partial credit modeling, we constructed three continuous latent variables, corresponding to TDP-43, Aβ/Tau, and a-synuclein related neuropathology endophenotype scores.
Method: Participant data were drawn from the National Alzheimer's Coordinating Center (NACC) neuropathology (NP) data (from the September 2023 data freeze) linked to Alzheimer's Disease Genetics Consortium (ADGC) genotype data.
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