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Urine organic acid metabolomic profiling by gas chromatography mass spectrometry: Assessment of solvent extract evaporation parameters on the recovery of key diagnostic metabolites.
Clin Chim Acta
January 2025
Department of Medical Biochemistry, Immunology & Toxicology, University Hospital Wales, Cardiff CF14 4XW, UK; School of Medicine, Cardiff University, University Hospital Wales, Cardiff CF14 4XN, UK.
Background: Analysis of urinary organic acids (UOAs) by gas chromatography mass-spectrometry (GC-MS) is widely used in metabolomic studies. It is a complex test with many limitations and pitfalls yet there is limited evidence in the literature to support best practice. This study investigated the impact of drying down time and temperature on the recovery of 16 key analytes from solvent extracts.
View Article and Find Full Text PDFAuthors reply to direct oral anticoagulants in thrombotic anti-phospholipid syndrome: Addressing misinterpretations in subgroup analysis.
Br J Haematol
November 2024
Department of Haematology, Guy's & St. Thomas' NHS Foundation Trust, London, UK.
The estimands framework: a primer on the ICH E9(R1) addendum.
BMJ
January 2024
MRC Clinical Trials Unit at UCL, University College London, London WC1V 6LJ, UK.
Estimands can be used in studies of healthcare interventions to clarify the interpretation of treatment effects. The addendum to the ICH E9 harmonised guideline on statistical principles for clinical trials (ICH E9(R1)) describes a framework for using estimands as part of a study. This paper provides an overview of the estimands framework, as outlined in the addendum, with the aim of explaining why estimands are beneficial; clarifying the terminology being used; and providing practical guidance on using estimands to decide the appropriate study design, data collection, and estimation methods.
View Article and Find Full Text PDFEstimating life expectancy and years of life lost for autistic people in the UK: a matched cohort study.
Lancet Reg Health Eur
January 2024
UCL Research Department of Clinical, Educational and Health Psychology, Division of Psychology and Language Sciences, 1 - 19 Torrington Place, London, WC1E 7HB, UK.
Background: Previous research has shown that people who have been diagnosed autistic are more likely to die prematurely than the general population. However, statistics on premature mortality in autistic people have often been misinterpreted. In this study we aimed to estimate the life expectancy and years of life lost experienced by autistic people living in the UK.
View Article and Find Full Text PDFEndemic statistical paradoxes in epidemiologic studies distort knowledge on prostate cancer: mitigation and caution of fallacies in prostate cancer causal epidemiological studies.
Curr Opin Urol
November 2023
Population Health Sciences, Bristol Medical School, University of Bristol.
Purpose Of Review: Many studies on epidemiology of prostate cancer (PCa) are based on a diagnosis of PCa using PSA (prostate-specific antigen) level. However, biases can distort the interpretation of the results, which in turn limits policy and decision making on public health prevention strategies or clinical guidelines. The main confusion is to interpret the posterior probability of the outcome following the exposure as a change in the prevalence of the disease outcome, whereas this change reflects only the predictive values of the PSA test induced by the exposure of interest.
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