AI Article Synopsis

  • Research has traditionally focused on skin bacteria as the main cause of surgical infections, but recent findings show that intestinal bacteria are actually the primary culprits in postoperative infections.
  • In experiments with mice, it was found that CCR6 group 3 innate lymphoid cells (ILC3s) play a crucial role in controlling bacterial spread after surgery by producing interleukin-22 (IL-22).
  • The study highlights that ILC3s are essential for liver regeneration and suggests they could be new targets for preventing infections linked to intestinal bacteria in postoperative patients.

Article Abstract

It is generally believed that environmental or cutaneous bacteria are the main origin of surgical infections. Therefore, measures to prevent postoperative infections focus on optimizing hygiene and improving asepsis and antisepsis. In a large cohort of patients with infections following major surgery, we identified that the causative bacteria are mainly of intestinal origin. Postoperative infections of intestinal origin were also found in mice undergoing partial hepatectomy. CCR6 group 3 innate lymphoid cells (ILC3s) limited systemic bacterial spread. Such bulwark function against host invasion required the production of interleukin-22 (IL-22), which controlled the expression of antimicrobial peptides in hepatocytes, thereby limiting bacterial spread. Using genetic loss-of-function experiments and punctual depletion of ILCs, we demonstrate that the failure to restrict intestinal commensals by ILC3s results in impaired liver regeneration. Our data emphasize the importance of endogenous intestinal bacteria as a source for postoperative infection and indicate ILC3s as potential new targets.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066576PMC
http://dx.doi.org/10.1016/j.celrep.2023.112269DOI Listing

Publication Analysis

Top Keywords

intestinal bacteria
8
liver regeneration
8
postoperative infections
8
intestinal origin
8
bacterial spread
8
intestinal
5
ilc3s
4
ilc3s restrict
4
restrict dissemination
4
dissemination intestinal
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!