AI Article Synopsis
- The study assessed the clinicopathological features of ocular papilloma, focusing on its recurrence and partial deterioration, involving 298 patients with an average age of 41.54 years.
- Key findings indicated that the most common sites of papilloma were bulbar conjunctiva, eyelid skin, and palpebral conjunctiva, with 16.28% experiencing recurrences and 3.59% showing malignant transformation.
- Results highlighted that having multiple lesions increased the risk of recurrence, while cryotherapy was effective in reducing this risk, and older patients with specific lesions had a higher chance of malignancy.*
Article Abstract
Purpose: This study aimed to analyze the clinicopathological features of ocular papilloma, a common benign tumor, and the risk factors related to its recurrence and partial deterioration.
Methods: We collected and analyzed the clinical information of 298 patients (51.68% males) with mean age of 41.54 ± 21.95 years, in the ophthalmology department of the West China Hospital. Clinical and pathological factors that might be related to papilloma recurrence and partial deterioration were studied.
Results: The top three papilloma sites were bulbar conjunctiva, eyelid skin and palpebral conjunctiva. Moreover, 3.59% of lesions presented a malignant transformation, and 16.28% of patients had one or more recurrences after an average follow-up of 4.47 years. The multivariate logistic regression model showed that multiple lesions were a risk factor for recurrence (p = 0.022, OR = 3.088, 95% CI: 1.180-8.079), while cryotherapy decreased the recurrence risk (p = 0.044, OR = 0.364, 95% CI: 0.136-0.972). Additionally, elderly patients and lesions on the corneal limbus or cornea had a higher risk of malignant transformation (p = 0.004 and 0.01, OR = 1.086 and 7.827, 95% CI: 1.027-1.150 and 1.629-37.596, respectively).
Conclusion: Ocular papilloma usually occurs in middle-aged and young patients, with no significant gender differences. Older patients and lesions on the corneal limbus or cornea are risk factors for partial malignant transformation. Finally, multiple lesions were a risk factor for recurrence, and cryotherapy reduced the recurrence rate.
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| http://dx.doi.org/10.1007/s00417-023-06035-y | DOI Listing |
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