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Pauciflorins A-E, Unexpected Chromone-Monoterpene-Derived Meroterpenoids from . | LitMetric

AI Article Synopsis

Article Abstract

Five unusual meroterpenoids based on new carbon skeletons, pauciflorins A-E (-), were isolated by multistep chromatographic separations of a methanol extract of the aerial parts of . Compounds - are derived by the connection of a 2-nor-chromone and a monoterpene unit, whereas and are dihydrochromone-monoterpene adducts with a rarely occurring orthoester functionality. The structures were solved using 1D and 2D NMR, HRESIMS, and single-crystal X-ray diffraction. Pauciflorins A-E were evaluated for antiproliferative activity against human gynecological cancer cell lines, but were inactive (IC < 10 μM) in each case.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152445PMC
http://dx.doi.org/10.1021/acs.jnatprod.2c01132DOI Listing

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