Cellular therapies show promise for treatment of fibrosis. A recent article presents a strategy and proof-of-concept for delivering stimulated cells to degrade hepatic collagen in vivo. A discussion is presented surrounding the strengths of this approach and the potential to generalize this strategy of optimizing cell sources and activation stimuli to treat other types of fibrosis.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265036PMC
http://dx.doi.org/10.1002/advs.202207396DOI Listing

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Response to a Comment on "Scar-Degrading Endothelial Cells as a Treatment for Advanced Liver Fibrosis".

Adv Sci (Weinh)

June 2023

Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China.

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Cellular therapies show promise for treatment of fibrosis. A recent article presents a strategy and proof-of-concept for delivering stimulated cells to degrade hepatic collagen in vivo. A discussion is presented surrounding the strengths of this approach and the potential to generalize this strategy of optimizing cell sources and activation stimuli to treat other types of fibrosis.

View Article and Find Full Text PDF

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