AI Article Synopsis
- - Antibiotic-associated diarrhea is a common side effect of antimicrobial therapy, and a study was conducted to examine its prevalence among pediatric patients in a specific region.
- - The study involved 758 pediatric patients who started oral antibiotics, revealing a 10.4% occurrence rate of diarrhea associated with antibiotic use, particularly higher with cephalosporins and in certain geographic areas of Turkey.
- - The findings highlighted geographic differences in the rate of antibiotic-associated diarrhea, suggesting that while it's not extremely common, it can vary significantly based on location and type of antibiotic used.
Article Abstract
Background: Antibiotic-associated diarrhea is one of the most frequent side effects of antimicrobial therapy. We assessed the epidemiological data of antibiotic-associated diarrhea in pediatric patients in our region.
Methods: The prospective multi-center study included pediatric patients who were initiated an oral antibiotic course in outpatient clinics and followed in a well-established surveillance system. This follow-up system constituded inclusion of patient by the primary physician, supply of family follow-up charts to the family, passing the demographics and clinical information of patient to the Primary Investigator Centre, and a close telephone follow-up of patients for a period of eight weeks by the Primary Investigator Centre.
Results: A result of 758 cases were recruited in the analysis which had a frequency of 10.4% antibiotic-associated diarrhea. Among the cases treated with amoxicillin-clavulanate 10.4%, and cephalosporins 14.4% presented with antibiotic-associated diarrhea. In the analysis of antibiotic-associated diarrhea occurrence according to different geographical regions of Turkey, antibiotic-associated diarrhea episodes differed significantly (p = 0.014), particularly higher in The Eastern Anatolia and Southeastern Anatolia. Though most commonly encountered with cephalosporin use, antibiotic-associated diarrhea is not a frequent side effect.
Conclusion: This study on pediatric antibiotic-associated diarrhea displayed epidemiological data and the differences geographically in our region.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024443 | PMC |
| http://dx.doi.org/10.1186/s12887-023-03939-w | DOI Listing |
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