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Resorcinol-based Bolaamphiphilic Quaternary Ammonium Compounds.
ChemMedChem
January 2025
Villanova University, Chemistry, 800 E Lancaster Ave, 19085, Villanova, UNITED STATES OF AMERICA.
Quaternary ammonium compounds (QACs) play crucial disinfectant roles in healthcare, industry, and domestic settings. Most commercially utilized QACs like benzalkonium chloride have a common architectural theme, leading to a rise in bacterial resistance and urgent need for novel structural classes. Some potent QACs such as chlorhexidine (CHX) and octenidine (OCT) feature a bolaamphiphilic architecture, comprised of two cationic centers at the molecular periphery and a non-polar region connecting them; these compounds show promise to elude bacterial resistance mechanisms.
View Article and Find Full Text PDFExpanding the Variety of Pyridinium-Based bis-QACs with Antimicrobial Properties: Investigation into Linker Structure-Activity Correlation.
ChemMedChem
January 2025
Zelinsky Institute of Organic Chemistry RAS: FGBUN Institut organiceskoj himii imeni N D Zelinskogo Rossijskoj akademii nauk, Organic Chemistry, RUSSIAN FEDERATION.
For decades quaternary ammonium compounds (QACs) have served as main component of a top antiseptic and disinfectant compositions. Among them, bis-QACs are the most prominent and effective class of biocides. Although mono-QACs still dominate the antiseptic market, their activity against Gram-negative bacteria is largely inferior to bis-QACs.
View Article and Find Full Text PDFSynthesis and evaluation of amino acid ionic liquid for enhanced oil recovery: experimental and modeling simulation studies.
Sci Rep
January 2025
Petrochemicals Department, Egyptian Petroleum Research Institute, 1 Ahmed El Zomor St., Nasr City, Cairo, 11727, Egypt.
Recovering the remaining oil after primary and secondary extraction methods poses a significant challenge. Enhanced oil recovery (EOR) techniques, which involve injecting fluids into reservoirs, aim to increase recovery rates. Ionic liquids, known for their adaptability, are emerging as promising agents in EOR, improving oil displacement by reshaping fluid properties and interacting with reservoir rocks.
View Article and Find Full Text PDFRecent developments in antimicrobial small molecule quaternary phosphonium compounds (QPCs) - synthesis and biological insights.
RSC Med Chem
January 2025
Department of Chemistry and Biochemistry, Villanova University Villanova PA 19085 USA
The development and characterization of quaternary phosphonium compounds (QPCs) have long benefitted from their incorporation into a cornerstone reaction in organic synthesis - the Wittig reaction. These structures have, more recently, been developed into a wide variety of novel applications, ranging from phase transfer catalysis to mitochondrial targeting. Importantly, their antimicrobial action has demonstrated great promise against a wide variety of bacteria.
View Article and Find Full Text PDFQuantitative Assessment of Microbial Transmission onto Environmental Surfaces Using Thermoresponsive Gelatin Hydrogels as a Finger Mimetic under In Situ-Mimicking Conditions.
Adv Healthc Mater
January 2025
Laboratory for Biointerfaces, Empa, Swiss Federal Laboratories for Materials and Technology, Lerchenfeldstrasse 5, St. Gallen, 9014, Switzerland.
Surface-mediated transmission of pathogens plays a key role in healthcare-associated infections. However, proper techniques for its quantitative analysis are lacking, making it challenging to develop novel antimicrobial and anti-fouling surfaces to reduce pathogen spread via environmental surfaces. This study demonstrates a gelatin hydrogel-based touch transfer test, the HydroTouch test, to evaluate pathogen transmission on high-touch surfaces under semi-dry conditions.
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