AI Article Synopsis
- The review examines the past, current, and future approaches to treating status epilepticus (SE), focusing on the mechanisms that keep seizures going, including presynaptic, postsynaptic, and extrasynaptic factors.
- It presents suitable antiseizure medications that can quickly stop SE based on the underlying mechanisms identified in research.
- The discussion also includes the challenges of applying new lab research findings to actual clinical practice for treating SE.
Article Abstract
The review presents retrospective, present views and future perspectives on the treatment of status epilepticus (SE). First, presynaptic, postsynaptic, and extrasynaptic mechanisms underlying sustaining ongoing seizure activity are highlighted. Next, mechanism-based choices of antiseizure medications capable of promptly arresting SE are introduced. Finally, challenges associated with translating the advances in laboratory research in clinical practice are discussed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173851 | PMC |
| http://dx.doi.org/10.1002/epi4.12725 | DOI Listing |
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