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| http://dx.doi.org/10.1111/cas.15784 | DOI Listing |
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Attributable Risk and Consequences of Bone Mineral Density Deficits in Childhood Cancer Survivors.
JAMA Netw Open
January 2025
Division of Endocrinology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Importance: Data characterizing the severity and changing prevalence of bone mineral density (BMD) deficits and associated nonfracture consequences among childhood cancer survivors decades after treatment are lacking.
Objective: To evaluate risk for moderate and severe BMD deficits in survivors and to identify long-term consequences of BMD deficits.
Design, Setting, And Participants: This cohort study used cross-sectional and longitudinal data from the St Jude Lifetime (SJLIFE) cohort, a retrospectively constructed cohort with prospective follow-up.
The Prognostic Value of Right Ventricular End-Diastolic Basal Diameter Index by Echocardiography in Connective Tissue Diseases Associated With Pulmonary Artery Hypertension.
Int J Rheum Dis
January 2025
Department of Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background: Right ventricular (RV) failure is a well-recognized pivotal prognostic factor of adverse outcomes in pulmonary artery hypertension (PAH), while RV dilation provides significant implications for adaptive or maladaptive changes. PAH is a predominant cause of mortality among patients with connective tissue disease (CTD). This study aims to elucidate the prognostic significance of RV morphology, as assessed by echocardiography (ECHO), in with CTD associated with PAH (CTD-PAH).
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Columbia University Irving Medical Center, New York, NY, USA.
Background: Recent advancements in connectome analyses allow for more fine-grained measurements of brain network integrity. One measure of integrity is resilience, or the capacity of the network to retain functionality when confronted with endogenous or exogenous perturbations that result in damage or error. We assessed the impact of individual differences in the resilience of resting BOLD connectivity on the relationship between cognitive and brain changes in a lifespan cohort of cognitively healthy adults over a 5-year period.
View Article and Find Full Text PDFBackground: The extracellular deposition of amyloid-beta (Aβ) and intracellular aggregation of hyperphosphorylated tau proteins stand as histopathological hallmarks of Alzheimer's disease (AD). The spatial-temporal relationship between the Aβ pathway and tau pathophysiology in AD, plays a crucial role in comprehending the pathogenesis and progression of AD. Understanding the interrelationship between Aβ and tau, is crucial to elucidate the failure of previous therapeutic strategies and understanding AD progression and will inform the next generation of clinical trials.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
University of California, San Francisco, San Francisco, CA, USA.
Background: Sleep and circadian disruption have been associated with cognitive impairment in older adults. However, little is known about the longitudinal change in 24-hour sleep-wake activity in oldest old adults and how profiles of sleep-wake changes may be associated with risk of mild cognitive impairment (MCI) and dementia.
Method: We studied 769 women (mean age = 82.
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