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CFTR Modulator Treatment in Children<12 Years of Age - Status Quo and Challenges.
Klin Padiatr
December 2024
Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School Centre for Paediatrics and Adolescent Medicine, Hannover, Germany.
Cystic fibrosis (CF) is a genetic disease that results from mutations in the CFTR gene. It primarily affects the lungs and digestive system. Recent advancements in the treatment of CF have been driven by highly effective therapies that modulate the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which target the underlying molecular defects in CFTR function.
View Article and Find Full Text PDFAdvancing Prognostic Prediction in Pediatric Trauma: The Role of Inflammatory Markers.
Klin Padiatr
December 2024
Department of Pediatrics, Istanbul Bagcilar Training and Research Hospital, Istanbul, Turkey.
Background: This study aimed to evaluate the prognostic value of various inflammatory markers and indices derived from complete blood counts in predicting mortality among pediatric trauma patients admitted to the Pediatric Intensive Care Unit (PICU).
Patients And Methods: We designed a single-center retrospective study that included 165 pediatric trauma patients in the PICU between January 2020 and June 2024.
Results: Of 165 patients, 108 (69.
Preclinical research progress in HER2-targeted small-molecule probes for breast cancer.
Radiologie (Heidelb)
November 2024
Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, 030032, Taiyuan, China.
Breast cancer is a malignant tumor that has the highest morbidity and mortality in women worldwide. Human epidermal growth factor receptor 2 (HER2) is a key driver of breast cancer development. Therefore, accurate assessment of HER2 expression in cancer patients and timely initiation or termination of anti-HER2 treatment are crucial for the prognosis of breast cancer patients.
View Article and Find Full Text PDF[Advances in breast cancer care].
MMW Fortschr Med
June 2024
Brustzentrum, Frauenklinik und CCC München, LMU Klinikum, Marchioninistr. 15, 81377, München, Deutschland.
Fortschritte bei der Metabolomik der atopischen Dermatitis: eine systematische Übersicht.
J Dtsch Dermatol Ges
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Department of Allergy, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
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