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Evaluation of clinical assessments of social abilities for use in autism clinical trials by the autism biomarkers consortium for clinical trials. | LitMetric

AI Article Synopsis

  • Clinical trials for autism spectrum disorder (ASD) often use clinician rating scales and parent surveys to assess behaviors, prompting the Autism Biomarkers Consortium for Clinical Trials (ABC-CT) to evaluate eight common assessment tools.
  • The study included 280 children with ASD and 119 neurotypical children, focusing on their ability to measure social communication and autism-related behaviors while ensuring they worked well across different demographic groups.
  • Results showed high data acquisition rates, all scales effectively distinguished between ASD and neurotypical groups, and varied levels of stability and intercorrelation among instruments, providing insights on their use in future clinical trials.

Article Abstract

Clinical trials in autism spectrum disorder (ASD) often rely on clinician rating scales and parent surveys to measure autism-related features and social behaviors. To aid in the selection of these assessments for future clinical trials, the Autism Biomarkers Consortium for Clinical Trials (ABC-CT) directly compared eight common instruments with respect to acquisition rates, sensitivity to group differences, equivalence across demographic sub-groups, convergent validity, and stability over a 6-week period. The sample included 280 children diagnosed with ASD (65 girls) and 119 neurotypical children (36 girls) aged from 6 to 11 years. Full scale IQ for ASD ranged from 60 to 150 and for neurotypical ranged from 86 to 150. Instruments measured clinician global assessment and autism-related behaviors, social communication abilities, adaptive function, and social withdrawal behavior. For each instrument, we examined only the scales that measured social or communication functioning. Data acquisition rates were at least 97.5% at T1 and 95.7% at T2. All scales distinguished diagnostic groups. Some scales significantly differed by participant and/or family demographic characteristics. Within the ASD group, most clinical instruments exhibited weak (≥ |0.1|) to moderate (≥ |0.4|) intercorrelations. Short-term stability was moderate (ICC: 0.5-0.75) to excellent (ICC: >0.9) within the ASD group. Variations in the degree of stability may inform viability for different contexts of use, such as identifying clinical subgroups for trials versus serving as a modifiable clinical outcome. All instruments were evaluated in terms of their advantages and potential concerns for use in clinical trials.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192100PMC
http://dx.doi.org/10.1002/aur.2905DOI Listing

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