is a Gram-negative marine bacterium that is a model system in the study of quorum sensing (QS). uses multichannel QS, mediated by three signaling molecules. The aim of this study was to synthesize and screen a diverse series of furanones for their potential to inhibit quorum sensing. A library of halogenated furanones was prepared and derivatized using standard Pd-mediated coupling reactions and subsequently evaluated for their effects on bioluminescence. Several furanones inhibited QS-regulated bioluminescence, with -dichlorofuranone and tribromofuranone compounds proving especially effective. Importantly, a number of compounds were effective inhibitors of bioluminescence but did not have an impact on bacterial growth.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4155/fmc-2022-0235 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
3,4-Dihalo-5-hydroxy-2(5)-furanones: Highly Reactive Small Molecules.
Molecules
October 2024
Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, Poland.
3,4-Dichloro-5-hydroxy-2(5)-furanone and its dibromo analog are highly reactive molecules. Both are members of the 2(5)-furanone family, which are important as pharmacophores present in drugs and natural products. Compounds possessing the 2(5)-furanone skeleton isolated from plants and marine organisms exhibit bioactivity against various microorganisms and viruses and can also be used in other medical treatments.
View Article and Find Full Text PDFMarine-Derived Furanones Targeting Quorum-Sensing Receptors in : Molecular Insights and Potential Mechanisms of Inhibition.
Bioinform Biol Insights
September 2024
Department of Chemistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
The quorum-sensing (QS) machinery in disease-causing microorganisms is critical in developing antibiotic resistance. In , QS is involved in biofilm formation, virulence factors production, and general tolerance to antimicrobials. Owing to the major role QS plays, interference in the process is probably a facile route to overcome antimicrobial resistance.
View Article and Find Full Text PDFDesigning novel anti-plasmodial quinoline-furanone hybrids: computational insights, synthesis, and biological evaluation targeting lactate dehydrogenase.
RSC Adv
June 2024
Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences India
To combat resistance against current antimalarials, modifying key pharmacophores and exploring novel parasite-specific drug targets remained one of the key drug design strategies. The resistance to quinoline-based antimalarials arises often due to the efflux of the drug. Hence, the development of newer agents containing bulkier pharmacophores will enable medicinal chemists to counteract drug resistance.
View Article and Find Full Text PDFAtmospheric oxidation of furanones by OH and Cl radicals: In situ FTIR rate coefficient determinations, SAR and theoretical studies.
Chemosphere
October 2023
(L.U.Q.C.A) Laboratorio Universitario de Química y Contaminación del Aire, Instituto de Investigaciones en Fisicoquímica de Córdoba (I.N.F.I.Q.C.), Dpto. De Fisicoquímica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, 5000, Córdoba, Argentina. Electronic address:
Gas-phase kinetics of the overall reactions of OH and Cl radicals with dihydrofuran-3(2H)-one (oxolan-3-one) and dihydro-2-methyl-3(2H)-furanone (2MTHF-3-one) were studied at 298 K and atmospheric pressure. The rate coefficients were determined using the relative method in a 480 L multipass glass reactor coupled to an FT-IR detection system. The rate coefficients found for oxolan 3-one and 2MTHF-one with OH radicals (k and k) and with Cl atoms (k and k) at 298 K and atmospheric pressure (in cm molecule s) were: k = (1.
View Article and Find Full Text PDFInvestigation of halogenated furanones as inhibitors of quorum sensing-regulated bioluminescence in .
Future Med Chem
February 2023
School of Pharmacy, University College Cork, Cork, T12 YN60, Ireland.
is a Gram-negative marine bacterium that is a model system in the study of quorum sensing (QS). uses multichannel QS, mediated by three signaling molecules. The aim of this study was to synthesize and screen a diverse series of furanones for their potential to inhibit quorum sensing.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!