A novel regioselective annulation of propargylic alcohols with simple carbazoles for the construction of [3,2,1-]carbazole scaffolds is described to be the first example of intermolecular synthesis of [3,2,1-]carbazoles from simple carbazoles. synthesis of propargyl alcohols from simple, cheap, and easily accessible ketones has also been developed during the one-pot synthesis of [3,2,1-]carbazoles.
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http://dx.doi.org/10.1021/acs.orglett.3c00244 | DOI Listing |
Cochrane Database Syst Rev
January 2025
Behaviour and Health Research Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Background: Overconsumption of food and consumption of any amount of alcohol increases the risk of non-communicable diseases. Calorie (energy) labelling is advocated as a means to reduce energy intake from food and alcoholic drinks. However, there is continued uncertainty about these potential impacts, with a 2018 Cochrane review identifying only a small body of low-certainty evidence.
View Article and Find Full Text PDFLangmuir
January 2025
Materials Chemistry Centre, Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, U.K.
Durable and fluorine-free superhydrophobic films were fabricated by a simple two-step process involving the pretreatment of glass substrates with an epoxysilane, which acted as an adhesive. The next step involved the aerosol-assisted chemical vapor deposition of a simple mixture of polydimethylsiloxane (PDMS) and SiO nanoparticles (NPs). Various parameters were studied, such as deposition time as well as PDMS and SiO loadings.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Department of Chemistry, College of Sciences, Northeastern University, Shenyang 110819, P. R. China.
Membranes have extensive applications in catalysis, separation, antimicrobial activities, and sensing. However, developing a simple and environmentally friendly method for preparing membranes remains challenging. Here, we report a novel strategy for fabricating self-standing inorganic-organic composite films at the miscible liquid/liquid interface using a soft spray technique.
View Article and Find Full Text PDFWorld Psychiatry
February 2025
School of Psychology, University of New South Wales, Sydney, NSW, Australia.
Although trauma-focused cognitive behavior therapy (TF-CBT) is the recommended treatment for post-traumatic stress disorder (PTSD), up to one-half of patients do not respond to this intervention. There is an urgent need to develop new strategies to improve treatment response. Training people to recall specific positive memories may augment treatment gains in TF-CBT.
View Article and Find Full Text PDFLangmuir
January 2025
Department of Chemistry and Biochemistry, Fordham University, 441 East Fordham Road, The Bronx, New York 10458, United States.
The first protocells are speculated to have arisen from the self-assembly of simple abiotic carboxylic acids, alcohols, and other amphiphiles into vesicles. To study the complex process of vesicle formation, we combined laboratory automation with AI-guided experimentation to accelerate the discovery of specific compositions and underlying principles governing vesicle formation. Using a low-cost commercial liquid handling robot, we automated experimental procedures, enabling high-throughput testing of various reaction conditions for mixtures of seven (7) amphiphiles.
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