A domino sulfonylation/intramolecular C-N coupling/dehydrogenation reaction was realized between pent-4-ynamides and sulfonyl chlorides by catalysis of Cu(acac) and 2,2'-bis(diphenylphosphanyl)-1,1'-binaphthalene. The reaction provides a convenient approach to sulfonyl-functionalized pyrrol-2-ones. This method can also be applied to the synthesis of 3-alkylidene isoindolinones from 2-ethynyl-benzamides.
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| http://dx.doi.org/10.1021/acs.orglett.3c00441 | DOI Listing |
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