Guillain-Barré syndrome (GBS) is an autoimmune neurological disorder with unknown aetiology. Given the incidence of GBS is between 1.2 and 1.9 cases per 100,000 people annually [1], it is extremely rare in pregnancy. We report a case with a challenging diagnosis of pre-eclampsia (PET) in a 34-year-old diabetic primigravida who was diagnosed with GBS at 30 weeks of gestation. At her initial presentation, she complained of progressive weakness of her limbs and facial muscles. This was associated with difficulty swallowing. The diagnosis of GBS was made based on electromyography (EMG) and clinical findings. She was managed conservatively with supportive management and was delivered by lower segment caesarean section at 34 weeks of gestation due to rapidly deteriorating liver function tests (LFTs) in the likely setting of PET.
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http://dx.doi.org/10.1016/j.crwh.2023.e00489 | DOI Listing |
Pregnancy Hypertens
January 2025
School of Health Professions, Faculty of Health, University of Plymouth, UK.
Background: Oral health may influence blood pressure control by modulating the abundance and activity of nitrate-reducing bacteria, which are essential for enhancing nitrite and nitric oxide (NO) bioavailability. This study aimed to investigate the oral health and microbiome composition of women with pre-eclampsia (PET) compared to healthy controls (CN).
Methods: Ten PET and eleven CN women participated in this study, respectively.
Clin Med (Lond)
December 2024
Women's Centre, John Radcliffe Hospital, Oxford University Hospitals, Headley Way, Headington, OX3 9DU. Electronic address:
Pregnancy leads to significant changes in renal physiology, which result in increases in glomerular filtration rate (GFR) and enhanced protein excretion. These changes may continue in the postnatal period and might be observed for 5-6 months after birth. Once confirmed, proteinuria warrants investigation and close surveillance.
View Article and Find Full Text PDFAust J Gen Pract
December 2024
BMed, Obstetrics and Gynaecology Senior Health Medical Officer, Joan Kirner Women@s and Children@s Hospital, Melbourne, Vic.
Background: Hypertensive disorders in pregnancy (HDIP) are among the leading causes of maternal and perinatal morbidity and mortality and should not be reserved for specialist care and expertise.1 General practitioners (GPs) are inevitably involved in the care of women with HDIP, particularly in the preconception, early pregnancy and postpartum periods and, also, as shared maternity care providers. It is, therefore, critical that GPs can assess and manage HDIP.
View Article and Find Full Text PDFHypertens Pregnancy
December 2024
OBGYN Consultant, Obstetrics and Gynecology Department, Arrayan Hospital, Dr Sulaiman Alhabib Medical Group, Riyadh, Saudi Arabia.
Objectives: Preeclampsia (PET) is a serious pregnancy complication with potential adverse maternal and fetal outcomes. Recent research has examined the soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio for predicting PET. The study aimed to assess the efficacy of the sFlt-1/PlGF ratio in ruling out unnecessary hospital admission and PET.
View Article and Find Full Text PDFPLoS One
September 2024
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.
Objectives: To determine the prevalence of proteinuria in patients diagnosed with intrahepatic cholestasis of pregnancy (IHCP), and the association between the presence of proteinuria and adverse pregnancy outcomes.
Methods: This was a retrospective cohort study. The study included all pregnant patients between July 2014 and January 2022, at gestational age > 24weeks who had been diagnosed with IHCP and had completed a 24-hour protein collection.
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