This study assesses a multi-period capacitated maximal-covering location-allocation model for healthcare services, taking interservice referral as well as equity access into account. A two-stage optimization strategy is used to formulate the model. In the first stage, facilities are located to maximize covered demand, and in the second stage, patients are allocated to capacitated facilities based on their radius of coverage over multiple time periods. The problem, which belongs to the NP-hard class of optimization problems, is solved using a linear mixed-integer programming (MILP) model. A numerical example is presented to evaluate the efficiency of the proposed model. In addition, to identify near-optimal solutions for large instances, a hybrid genetic-sequential quadratic programming approach (GA-SQP) is developed. To examine the performance and efficiency of the GA-SQP, we employed several randomly generated test instances of various sizes and compared them to those obtained using the exact method. The proposed model has demonstrated an excellent ability in locating healthcare facilities and allocating health services while taking shortage and equity into account during each time period.
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http://dx.doi.org/10.3389/ijph.2023.1605015 | DOI Listing |
In 2019, the novel coronavirus swept the world, exposing the monitoring and early warning problems of the medical system. Computer-aided diagnosis models based on deep learning have good universality and can well alleviate these problems. However, traditional image processing methods may lead to high false positive rates, which is unacceptable in disease monitoring and early warning.
View Article and Find Full Text PDFCureus
December 2024
Epidemiology and Public Health, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, JPN.
Introduction Climate change is a decisive factor affecting human health. While many epidemiological studies have investigated the acute impacts of ambient temperature on mortality and morbidity, the global burden of infectious gastroenteritis linked to temperature changes remains largely unexplored. Therefore, we aimed to examine the exposure-response associations between ambient temperature and infectious gastroenteritis incidence throughout Japan and quantify the temperature-related morbidity burden.
View Article and Find Full Text PDFPathogens
December 2024
Infectious Disease Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Brain abscesses are invasive infections of the central nervous system with a high level of treatment complexity especially in pediatric patients. Here, we describe a 3-month-old infant with multiple brain abscesses caused by methicillin-susceptible (MSSA). The patient was initially treated with empirical antibiotics (ceftriaxone, metronidazole, vancomycin).
View Article and Find Full Text PDFBiomimetics (Basel)
January 2025
Automotive Parts Research Institute, Hunan University of Technology, Hengyang 421002, China.
This study investigates the unsteady aerodynamic mechanisms underlying the efficient flight of birds and proposes a biomimetic flapping-wing aircraft design utilizing a double-crank double-rocker mechanism. Building upon a detailed analysis of avian flight dynamics, a two-stage foldable flapping mechanism was developed, integrating an optimized double-crank double-rocker structure with a secondary linkage system. This design enables synchronized wing flapping and spanwise folding, significantly enhancing aerodynamic efficiency and dynamic performance.
View Article and Find Full Text PDFTheor Appl Genet
January 2025
Grasslands Research Centre, AgResearch Ltd, Private Bag 11008, Palmerston North, 4442, New Zealand.
Genomic selection using white clover multi-year-multi-site data showed predicted genetic gains through integrating among-half-sibling-family phenotypic selection and within-family genomic selection were up to 89% greater than half-sibling-family phenotypic selection alone. Genomic selection, an effective breeding tool used widely in plants and animals for improving low-heritability traits, has only recently been applied to forages. We explored the feasibility of implementing genomic selection in white clover (Trifolium repens L.
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