AI Article Synopsis
- Chondroitin sulfate (CS) is crucial for bone health, aiding in processes like biomineralization and healing, though its exact function remains unclear.
- Recent research revealed that CS promotes mineralization of collagen only when it is free in the extracellular matrix, with higher concentrations leading to better mineralization.
- The findings suggest CS could be a potential treatment for conditions like heterotopic ossification and highlight its potential use in tissue engineering.
Article Abstract
Chondroitin sulfate (CS) is an important extracellular matrix component of mineralized tissues. It participates in biomineralization, osteoblast differentiation and promotes bone tissue repair in vitro. However, the mechanism in which CS functions is unclear. Accordingly, an in-depth investigation of how CS participates in mineralization was conducted in the present study. Chondroitin sulfate was found to directly induce intrafibrillar mineralization of the collagen matrix. The mineralization outcome was dependent on whether CS remained free in the extracellular matrix or bound to core proteins; mineralization only occurred when CS existed in a free state. The efficacy of mineralization appeared to increase with ascending CS concentration. This discovery spurred the authors to identify the cause of heterotopic ossification in the Achilles tendon. Chondroitin sulfate appeared to be a therapeutic target for the management of diseases associated with heterotopic calcification. A broader perspective was presented on the applications of CS in tissue engineering.
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| http://dx.doi.org/10.1016/j.carbpol.2023.120738 | DOI Listing |
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