Enamel thickness of the maxillary permanent central incisors and canines in seven Finnish 47,XXX females, their first-degree male and female relatives, and control males and females from the general population were determined from radiographs. The results showed that enamel in teeth of 47,XXX females was clearly thicker than that of normal controls. On the other hand, the thickness of "dentin" (distance between mesial and distal dentinoenamel junctions) in 47,XXX females' teeth was about the same as that in normal control females, but clearly reduced as compared with that in control males. It is therefore obvious that in the triple-X chromosome complement the extra X chromosome is active in amelogenesis, whereas it has practically no influence on the growth of dentin. The calculations based on present and previous results in 45,X females and 47,XYY males indicate that the X chromosome increases metric enamel growth somewhat more effectively than the Y chromosome. Possibly, halfway states exist between active and repressed enamel genes on the X chromosome. The Y chromosome seems to promote dental growth in a holistic fashion.
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