AI Article Synopsis
- Bacterial bone infections in open fractures are a significant challenge in orthopedics, highlighting the need for effective treatments.
- Antimicrobial peptides (AMPs) show promise as alternatives to traditional antibiotics due to their ability to combat bacteria without promoting resistance.
- The review discusses the structure and mechanisms of AMPs, highlights key peptides like LL-37 and β-defensins, and examines strategies for delivering AMPs with bioactive materials to improve healing and reduce complications in bone infections.
Article Abstract
Bacterial bone infection in open fractures is an urgent problem to solve in orthopedics. Antimicrobial peptides (AMPs), as a part of innate immune defense, have good biocompatibility. Their antibacterial mechanism and therapeutic application against bacteria have been widely studied. Compared with traditional antibiotics, AMPs do not easily cause bacterial resistance and can be a reliable substitute for antibiotics in the future. Therefore, various physical and chemical strategies have been developed for the combined application of AMPs and bioactive materials to infected sites, which are conducive to maintaining the local stability of AMPs, reducing many complications, and facilitating bone infection resolution. This review explored the molecular structure, function, and direct and indirect antibacterial mechanisms of AMPs, introduced two important AMPs (LL-37 and β-defensins) in bone tissues, and reviewed advanced AMP loading strategies and different bioactive materials. Finally, the latest progress and future development of AMPs-loaded bioactive materials for the promotion of bone infection repair were discussed. This study provided a theoretical basis and application strategy for the treatment of bone infection with AMP-loaded bioactive materials.
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| http://dx.doi.org/10.1016/j.colsurfb.2023.113255 | DOI Listing |
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