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Adult living-donor lobar lung transplant using a small-for-size graft.
Eur J Cardiothorac Surg
November 2024
Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Objectives: This study was designed to examine the outcomes of adult living-donor lobar lung transplants (LDLLTs) using small-for-size grafts.
Methods: A calculated graft forced vital capacity of <50% of the predicted forced vital capacity of the recipient was considered to indicate a small-for-size graft. Adult recipients (≥18 years) who underwent LDLLTs between 2008 and 2022 were included in this study.
Lobar graft evaluation in cadaveric lobar lung redo transplantation after living-donor lobar lung transplantation: a case report.
Surg Case Rep
October 2024
Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryomachi, Aobaku, Sendai, Miyagi, 980-8575, Japan.
Background: Lung transplantation is a vital option for patients with end-stage lung disease. However, it faces a significant challenge due to the shortage of compatible donors, which particularly affects individuals with small chest cavities and pediatric patients. The novel approach of cadaveric lobar lung transplantation is a promising solution to alleviate the donor shortage crisis.
View Article and Find Full Text PDFDifferences in chronic lung allograft dysfunction between deceased-donor lung transplantation and living-donor lobar lung transplantation.
J Thorac Cardiovasc Surg
October 2024
Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan.
Article Synopsis
- This study investigates chronic lung allograft dysfunction (CLAD) following deceased-donor and living-donor lung transplants to unveil differences in their characteristics and prognosis.
- Data from 123 deceased-donor and 67 living-donor lung transplants were analyzed, highlighting that living-donor transplants had fewer human leukocyte antigen mismatches and better outcomes in some clinical aspects.
- Although living-donor transplants had a higher occurrence of restrictive allograft syndrome, overall survival rates after transplantation and post-CLAD onset were similar between both transplant groups, with living-donor grafts showing a lower cumulative incidence of CLAD compared to deceased-donor grafts.
Living-donor lobar lung transplantation for pulmonary Langerhans cell histiocytosis complicated by extensive thrombi in central pulmonary arteries.
Surg Case Rep
July 2024
Department of Thoracic Surgery, Kyoto University Hospital, 54 Shogoin Kawahara-Cho, Sakyo-Ku, Kyoto, 606-8507, Japan.
Background: Pulmonary Langerhans cell histiocytosis (PLCH) is a rare disorder characterized by the proliferation of Langerhans cells along the small airways, which causes nodular and cystic changes in the lung parenchyma. Lung transplantation can be a life-saving option for patients with severe respiratory failure or pulmonary hypertension. Herein, we present a case of successful lung transplantation in a patient with PLCH who developed unusually large thrombi in the central pulmonary artery.
View Article and Find Full Text PDFLiving-donor Lobar Lung Transplantation - Initiation and Development - Secondary Publication.
JMA J
April 2024
Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Due to the difficulty of finding brain-dead donors, in October 1998, I performed the first living-donor lobar lung transplantation (LDLLT) for a ventilator-dependent 24-year-old female patient with bronchiectasis using lobes from her parents. The patient is still alive and in good health 25 years after the transplantation. Over time, the indications for LDLLT have expanded to include pulmonary hypertension, pulmonary fibrosis, congenital genetic diseases, pulmonary complications after stem cell transplantation, and, more recently, severe lung injury due to COVID-19 infection.
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