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Incomplete ovarian function suppression in premenopausal breast cancer patients treated with gonadotropin-releasing hormone agonists.
Cancer Treat Rev
January 2025
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120 Guangzhou, China; Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120 Guangzhou, China. Electronic address:
Background: Ovarian function suppression (OFS) has emerged as a crucial adjuvant therapy for premenopausal breast cancer patients. Some patients fail to achieve complete OFS with commonly used OFS drugs. The definition of incomplete OFS remains unclear, and large-scale data on its incidence are lacking.
View Article and Find Full Text PDFRecurrent Low-grade endometrial stromal sarcoma metastasized to the common iliac veins, extending into the inferior vena cava and right atrium after 12 years: A case report.
Gynecol Oncol Rep
December 2024
Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Introduction: Extrauterine recurrent metastasis of Low-grade endometrial stromal sarcoma (LG-ESS) to major blood vessels is largely rare with few reported cases.
Case: Herein, we present a case of a 51-year-old female with recurrent LG-ESS that has metastasized after 12 years to the inferior vena cava (IVC) and extended into the right atrium and common iliac veins. Computed tomography showed an intracardiac larger thrombus within the right atrium extending into the inferior vena cava and common iliac veins.
[A Case of Breast Cancer Recurrence 32 Years after Primary Surgery].
Gan To Kagaku Ryoho
December 2024
Dept. of Surgery, Kikkoman General Hospital.
Article Synopsis
- An 80-year-old woman with a history of breast cancer presented with bloody sputum and multiple lung nodules, diagnosed as metastases through a biopsy.
- Initial treatment with denosumab and an aromatase inhibitor led to a 3-year period of tumor shrinkage, followed by regrowth of peritoneal metastases.
- After experiencing severe side effects from second-line chemotherapy, fulvestrant was administered, resulting in long-term tumor shrinkage without negatively impacting her quality of life; this case highlights a rare recurrence of breast cancer 32 years post-surgery.
Steroid Profiles and Precursor-to-Product Ratios Are Altered in Pregnant Women with Preeclampsia.
Int J Mol Sci
November 2024
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria.
Steroid hormone imbalance is associated with the pathogenesis of preeclampsia. However, affected enzymes of steroid metabolism and gene and protein expression in serum and placenta have not been elucidated yet. We aimed to investigate steroid hormone profiles and precursor-to-product ratios in preeclamptic women compared to women with healthy pregnancy (controls) to identify potentially affected steroid hormones and their metabolizing enzymes.
View Article and Find Full Text PDFLong term effects of aromatase inhibitor treatment in patients with aromatase excess syndrome.
Front Endocrinol (Lausanne)
December 2024
Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.
Article Synopsis
- Aromatase excess syndrome (AEXS) is a rare genetic disorder that leads to excessive conversion of androgens to estrogens, causing issues like gynecomastia and delayed puberty in males, and fewer cases reported in females.
- A family study revealed that all four members with AEXS shared a specific genetic deletion, and the long-term use of aromatase inhibitors like letrozole improved symptoms such as accelerated growth and gynecomastia.
- Treatment outcomes varied among family members: significant gains in adult height and reduction of gynecomastia were noted in the male patients, while the female sibling experienced normal puberty development and growth with a combination of therapies.*
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