The purpose of this study is to develop and empirically test a structural equation model (SEM) for healthy and effective self-regulation based on the propositions of self-determination theory (SDT). A cross-sectional data sample ( = 6,705) is used to test the model. The results of the SEM demonstrate good to excellent global fit indices (RMSEA = 0.06, SRMR = 0.04 CFI = 0.97, TLI/NNFI = 0.95) and excellent local fit indices ( < 0.001). It is acknowledged that longitudinal and experimental research designs will be necessary to infer causal effects. However, based on the strong theoretical and empirical grounding of the model, indications for causal effects are discussed beyond correlational relations. The local fit indices imply that autonomy of goals, intrinsic values orientation, mindfulness, and the newly integrated construct clarity about personal values positively affect psychological needs satisfaction and facets of subjective and psychological well-being. Additionally, they indicate that mindfulness and clarity about personal values have the greatest benefits on individual health, well-being, and effectiveness. These results are crucial as they emphasize the significant role of mindfulness in healthy and effective self-regulation. Furthermore, they put the spotlight on a rather new construct; clarity about personal values. By having transferred the knowledge base of SDT into an empirically derived model of healthy and effective self-regulation, this study provides well-grounded indications of how health, well-being, and effectiveness in individuals may be fostered. These indications offer new insights for theory building and practical interventions in domains like psychotherapy, healthcare, organizations, sports, and education.
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http://dx.doi.org/10.1016/j.ijchp.2023.100375 | DOI Listing |
Eur J Trauma Emerg Surg
January 2025
Department of Trauma Surgery and Orthopedics, Goethe University, University Hospital, Frankfurt, Germany.
Objective: Global per capita alcohol consumption is increasing, posing significant socioeconomic and medical challenges also due to alcohol-related traumatic injuries but also its biological effects. Trauma as a leading cause of death in young adults, is often associated with an increased risk of complications, such as sepsis and multiple organ failure, due to immunological imbalances. Regulatory T cells play a crucial role in maintaining immune homeostasis by regulating the inflammatory response.
View Article and Find Full Text PDFInn Med (Heidelb)
January 2025
Lehrstuhl für Ernährung und Immunologie, School of Life Sciences, Technische Universität München, Gregor-Mendel-Straße 2, 85354, Freising, Deutschland.
Background: The intestinal microbiota comprises all living microorganisms in the gastrointestinal tract and is crucial for its function. Clinical observations and laboratory findings confirm a central role of the microbiota in chronic inflammatory bowel diseases (IBD). However, many mechanistic details remain unclear.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Internal Medicine, Afzalipour Faculty of Medicine, Afzalipour Hospital Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Inflammation and oxidative stress play a pivotal role in COPD pathogenesis. Free fatty acids (FFA) as signaling molecules through a series of G-proteins coupled receptors, play an important role in regulation of the immune system and oxidative stress. For this reason, we decided to investigate the profile of FFA in the plasma in the COPD patients.
View Article and Find Full Text PDFNephrol Dial Transplant
January 2025
Clinica Medica, University Milano-Bicocca and University of Milano-Bicocca, Milan, Italy.
The autonomic nervous system plays a crucial role in regulating physiological processes and maintaining homeostasis through its two branches: the sympathetic nervous system (SNS) and the parasympathetic nervous system. Dysregulation of the autonomic system, characterized by increased sympathetic activity and reduced parasympathetic tone, is a common feature in chronic kidney disease (CKD) and cardiovascular disease. This imbalance contributes to a pro-inflammatory state, exacerbating disease progression and increasing the risk for cardiovascular events.
View Article and Find Full Text PDFAm J Clin Nutr
January 2025
Department of Human Biology, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, the Netherlands. Electronic address:
Background: Industrial processing and storage of milk products can strongly increase protein glycation level. Previously, we have reported that ingestion of highly glycated milk protein attenuates the post-prandial rise in plasma lysine concentrations when compared to the ingestion of an equivalent amount of milk protein with a low glycation level. Whether the attenuated increase in plasma lysine availability is attributed to compromised protein digestion and subsequent lysine absorption remains to be established.
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