AI Article Synopsis
- Sex chromosome disorders disrupt the formation of gametes (sperm and eggs) in males and females, particularly affecting egg production when there are abnormalities in X or Y chromosomes.* -
- Researchers managed to convert XY mouse stem cells to an XX chromosome set, eliminating certain conditions like trisomy 16, a model for Down's syndrome, leading to successful production of mature oocytes.* -
- This breakthrough allows the possibility of creating fully functional oocytes from male stem cells, potentially addressing infertility issues and enabling potentially bipaternal reproduction in the future.*
Article Abstract
Sex chromosome disorders severely compromise gametogenesis in both males and females. In oogenesis, the presence of an additional Y chromosome or the loss of an X chromosome disturbs the robust production of oocytes. Here we efficiently converted the XY chromosome set to XX without an additional Y chromosome in mouse pluripotent stem (PS) cells. In addition, this chromosomal alteration successfully eradicated trisomy 16, a model of Down's syndrome, in PS cells. Artificially produced euploid XX PS cells differentiated into mature oocytes in culture with similar efficiency to native XX PS cells. Using this method, we differentiated induced pluripotent stem cells from the tail of a sexually mature male mouse into fully potent oocytes, which gave rise to offspring after fertilization. This study provides insights that could ameliorate infertility caused by sex chromosome or autosomal disorders, and opens the possibility of bipaternal reproduction.
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| http://dx.doi.org/10.1038/s41586-023-05834-x | DOI Listing |
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