During cataract surgery, the intraocular temperature changes when irrigating low-temperature fluid and ophthalmic viscosurgical devices (OVDs) are inserted in the anterior chamber, and such a temperature variation affects the unfolding of the intraocular lens (IOL). A porcine eye holder was developed for simulating temperature conditions in clinical surgery by maintaining the ocular temperature close to the body temperature. An aluminum holder was designed to fit porcine eyes and maintain the ocular temperature at approximately 36 °C, while surgery was performed at a room temperature of 20 °C. Intraocular temperature was monitored using a thermocouple sensor placed close to the posterior capsule in the vitreous cavity. Temperatures and microscopic image of the anterior chamber were simultaneously recorded. With the use of the eye holder system, the intraocular temperature unstable during surgery was observed, and there were significant reductions during hydrodissection, irrigation and aspiration, OVD insertion in the capsule, and OVD removal after IOL implantation.
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http://dx.doi.org/10.1038/s41598-023-31070-4 | DOI Listing |
Int J Ophthalmol
December 2024
Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Aim: To investigate the biocompatibility and bacterial adhesion properties of light responsive materials (LRM) and analyze the feasibility and biosafety of employing LRM in the preparation of accommodative intraocular lenses (AIOLs).
Methods: Employing fundamental experimental research techniques, LRM with human lens epithelial cells (hLECs) and human retinal pigment epithelium cells (ARPE-19 cells) were co-cultured. Commercially available intraocular lenses (IOLs) were used as controls to perform cell counting kit-8 (CCK-8), cell staining under varying light intensities, cell adhesion and bacterial adhesion experiments.
Graefes Arch Clin Exp Ophthalmol
December 2024
Kaiya Eye Clinic, Hamamatsu, Shizuoka, Japan.
Purpose: Little is known about the effects of ambient atmospheric pressure (AP) on intraocular pressure (IOP) under ordinary conditions. This study aimed to investigate the effects of AP on Goldmann applanation tonometer-measured IOP (GAT-IOP) in normal eyes under everyday atmospheric conditions adjusting for effects of possible confounding factors including other climatic factors.
Methods: Data obtained from 2,431 normal healthy eyes of 2,431 subjects (mean age: 56.
Bioengineering (Basel)
October 2024
Department of Civil, Chemical and Environmental Engineering, University of Genoa, Via Montallegro 1, 16145 Genoa, Italy.
Emulsification is a feared and common complication of the use of silicone oil (SO) as tamponade fluid after vitrectomy as it potentially associated with significant risks to ocular health, including elevated intraocular pressure (IOP), glaucoma, corneal and retinal changes. The aim of this study was to investigate the role and interplay of physical factors on the formation of SO emulsion. Experiments were performed in a model of the vitreous chamber with a realistic shape, filled with SO and an aqueous solution containing different concentrations of albumin, an endogenous protein known to modify the interfacial properties between SO and aqueous solutions.
View Article and Find Full Text PDFJ Cataract Refract Surg
October 2024
Intermountain Ocular Research Center, Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
Methods Mol Biol
October 2024
Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA.
Experimental elevation of intraocular pressure (IOP), a major glaucoma risk factor, has been a mainstay of research into mechanisms of glaucomatous optic nerve damage for decades. Methods that produce sustained IOP elevation can mimic the chronic nature of glaucoma and produce optic nerve damage. However, the pressure course for individual animals can be variable, unpredictably high at times, and difficult to monitor with current tonometry methods.
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