Objectives: This study aimed to investigate the genetic association between (A1298C) SNP and preeclampsia (PE) in Punjab, Pakistan.
Methods: A sample of 80 pregnant women (40 healthy pregnant women and 40 with PE) was pooled for genotyping A1298C polymorphism by using the tetra-primer amplification refractory mutation system (ARMS) PCR. The Genotypic and allelic assessments were performed using various statistical techniques.
Results: The AC genotype and C allele of A1298C were found to be associated with decreased risk of PE (odds ratio [OR]: 0.31, risk ratio [RR]: 0.58, p = 0.01), and (odds ratio [OR]: 0.49, risk ratio [RR]: 0.61, p = 0.04), respectively.
Conclusion: In conclusion, genetic polymorphism A1298C in may pose a protective effect in the studied population.
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| http://dx.doi.org/10.1080/10641955.2023.2187621 | DOI Listing |
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