A treatment plan optimization method with direct minimization of number of energy jumps for proton arc therapy.

. The optimization of energy layer distributions is crucial to proton arc therapy: on one hand, a sufficient number of energy layers is needed to ensure the plan quality; on the other hand, an excess number of energy jumps (NEJ) can substantially slow down the treatment delivery. This work will develop a new treatment plan optimization method with direct minimization of (NEJ), which will be shown to outperform state-of-the-art methods in both plan quality and delivery efficiency.. The proposed method jointly optimizes the plan quality and minimizes the NEJ. To minimize NEJ, (1) the proton spotsis summed per energy layer to form the energy vector; (2)is binarized via sigmoid transform into; (3)is multiplied with a predefined energy order vector via dot product into; (4)is filtered through the finite-differencing kernel intoin order to identify NEJ; (5) only the NEJ ofis penalized, whileis optimized for plan quality. The solution algorithm to this new method is based on iterative convex relaxation.. The new method is validated in comparison with state-of-the-art methods called energy sequencing (ES) method and energy matrix (EM) method. In terms of delivery efficiency, the new method had fewer NEJ, less energy switching time, and generally less total delivery time. In terms of plan quality, the new method had smaller optimization objective values, lower normal tissue dose, and generally better target coverage.. We have developed a new treatment plan optimization method with direct minimization of NEJ, and demonstrated that this new method outperformed state-of-the-art methods (ES and EM) in both plan quality and delivery efficiency.