AI Article Synopsis
- Diacylglycerol acts as a key signaling molecule in cells, especially in T cells, where its levels are controlled by diacylglycerol kinases (DGKs).
- DGKα is crucial for managing TCR-mediated activation of CD8 T cells during specific viral infections like lymphocytic choriomeningitis.
- Without DGKα, T cell responses escalate into harmful inflammation, leading to severe immune-related damage and potential death in infected mouse models.
Article Abstract
Diacylglycerol is a potent element of intracellular secondary signaling cascades whose production is enhanced by cell-surface receptor agonism and function is regulated by enzymatic degradation by diacylglycerol kinases (DGKs). In T cells, stringent regulation of the activity of this second messenger maintains an appropriate balance between effector function and anergy. In this article, we demonstrate that DGKα is an indispensable regulator of TCR-mediated activation of CD8 T cells in lymphocytic choriomeningitis virus Clone 13 viral infection. In the absence of DGKα, Clone 13 infection in a murine model results in a pathologic, proinflammatory state and a multicellular immunopathologic host death that is predominantly driven by CD8 effector T cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121876 | PMC |
| http://dx.doi.org/10.4049/jimmunol.2101011 | DOI Listing |
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