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Spatial mapping reveals granuloma diversity and histopathological superstructure in human tuberculosis. | LitMetric

AI Article Synopsis

  • The study investigates the spatial organization of immune cells in human lung tissues affected by tuberculosis (TB), focusing on the formation of granulomas.
  • It identifies two main types of granulomas: necrotizing and non-necrotizing leukocyte aggregates, highlighting their diverse cellular composition.
  • The research reveals that the presence and composition of non-necrotizing aggregates near necrotizing lesions are indicative of distinct immune responses, suggesting a complex histopathological structure within TB-infected lung tissue.

Article Abstract

The hallmark of tuberculosis (TB) is the formation of immune cell-enriched aggregates called granulomas. While granulomas are pathologically diverse, their tissue-wide heterogeneity has not been spatially resolved at the single-cell level in human tissues. By spatially mapping individual immune cells in every lesion across entire tissue sections, we report that in addition to necrotizing granulomas, the human TB lung contains abundant non-necrotizing leukocyte aggregates surrounding areas of necrotizing tissue. These cellular lesions were more diverse in composition than necrotizing lesions and could be stratified into four general classes based on cellular composition and spatial distribution of B cells and macrophages. The cellular composition of non-necrotizing structures also correlates with their proximity to necrotizing lesions, indicating these are foci of distinct immune reactions adjacent to necrotizing granulomas. Together, we show that during TB, diseased lung tissue develops a histopathological superstructure comprising at least four different types of non-necrotizing cellular aggregates organized as satellites of necrotizing granulomas.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035589PMC
http://dx.doi.org/10.1084/jem.20221392DOI Listing

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