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MSCs-derived EVs protect against chemotherapy-induced ovarian toxicity: role of PI3K/AKT/mTOR axis.
J Ovarian Res
November 2024
Department of Medical Histology and Cell Biology Faculty of Medicine, Benha University, Benha, Egypt.
Article Synopsis
- Chemotherapy can lead to ovarian failure and complications related to estrogen deficiency by depleting follicular reserves in the ovaries, and current fertility preservation techniques face significant challenges.
- This study investigates the effects of exosomes derived from mesenchymal stem cells (MSCs) on ovarian function in a model of chemotherapy-induced ovarian failure, comparing several treatment groups.
- Results showed that MSCs-EVs therapy helped restore hormonal levels, preserve ovarian follicles, and reduce cell apoptosis, suggesting that this treatment could protect ovarian function and fertility during chemotherapy.
Erythropoietin effects on cryopreserved/transplanted cat ovarian tissue: A comparison of two incubation methods.
Cryobiology
June 2024
University of Brasilia, Institute of Biological Sciences, Department of Physiological Sciences, Brasilia-DF, 70910-900, Brazil. Electronic address:
Many feline species are currently threatened with extinction. Therefore, germplasm bank establishment has become imperative. However, cryoinjury and ischemia-reperfusion injury pose significant obstacles to both cryopreservation and xenotransplantation.
View Article and Find Full Text PDFTherapeutic approaches for Type 1 Diabetes: Promising cell-based approaches to achieve ultimate success.
SLAS Discov
January 2024
Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:
Article Synopsis
- * The shortage of suitable donor organs limits the potential of transplanting insulin-producing cells, leading researchers to explore stem cells as an alternative source for generating these cells.
- * Recent advancements highlight the use of β-cell specific transcription factors to enhance the generation of insulin-producing cells from various cell types, showing promise in improving treatments for T1DM.
Late acquisition of the rTCA carbon fixation pathway by Chlorobi.
Nat Ecol Evol
September 2023
Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
The reverse tricarboxylic acid (rTCA) cycle is touted as a primordial mode of carbon fixation due to its autocatalytic propensity and oxygen intolerance. Despite this inferred antiquity, however, the earliest rock record affords scant supporting evidence. In fact, based on the chimeric inheritance of rTCA cycle steps within the Chlorobiaceae, even the use of the chemical fossil record of this group is now subject to question.
View Article and Find Full Text PDFEnRDeA U-Net Deep Learning of Semantic Segmentation on Intricate Noise Roads.
Entropy (Basel)
July 2023
School of Information Science and Technology, Sanda University, No. 2727 Jinhai Road, Shanghai Pudong District, Shanghai 201209, China.
Road segmentation is beneficial to build a vision-controllable mission-oriented self-driving bot, e.g., the Self-Driving Sweeping Bot, or SDSB, for working in restricted areas.
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