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| http://dx.doi.org/10.1503/cmaj.221540 | DOI Listing |
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Periorbital purpura can be the only initial symptom of primary light chain amyloidosis: A case report.
World J Clin Cases
September 2024
Department of Hematology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, Henan Province, China.
Background: Primary light chain amyloidosis is a rare and complex disease with complex clinical features and is highly susceptible to misdiagnosis and underdiagnosis in the early stages.
Case Summary: We report a case of a 47-year-old female patient whose only initial symptom was periorbital purpura, which was not taken seriously enough. As the disease progressed, pleural effusion gradually appeared, and after systematic diagnosis and treatment, she was diagnosed with "primary light chain amyloidosis".
Immunoglobulin A vasculitis with periorbital edema and severe renal involvement: A case report.
Pediatr Dermatol
August 2024
Department of Dermatology, University of New Mexico (UNM), Albuquerque, New Mexico, USA.
Immunoglobulin A (IgA) vasculitis, or Henoch-Schonlein purpura, is the most common systemic vasculitis in children, clinically presenting as palpable purpura in combination with arthritis, gastrointestinal involvement, or kidney injury. Subcutaneous edema is reported in patients with IgA vasculitis, and it commonly affects the lower extremities, especially around joints. Here, we report a case of IgA vasculitis with a rare presentation of edema isolated to the periorbital area in a 7-year-old boy, who subsequently developed crescentic glomerulonephritis with nephrotic range proteinuria.
View Article and Find Full Text PDFA Case of Lepromatous Leprosy (Lucio's Phenomenon) Presenting as Periorbital Edema.
Ophthalmic Plast Reconstr Surg
July 2024
Department of Ophthalmology.
Despite low prevalence of leprosy worldwide, new cases continue to present and require swift evaluation and diagnosis to prevent complications. Here, we describe a case of lepromatous leprosy with Lucio's phenomenon initially presenting with facial and periorbital edema. A 38-year-old Brazilian woman presented to the emergency department with facial swelling and erythema, initially treated as cellulitis.
View Article and Find Full Text PDFImmune thrombocytopenia in the setting of acute SARS-CoV-2 infection.
BMJ Case Rep
June 2023
Pediatria Geral, Hospital de Vila Franca de Xira, E P E, Vila Franca de Xira, Portugal.
Immune thrombocytopenia (ITP) is an immune-mediated event, characterised by the destruction of platelets by autoantibodies resulting in isolated thrombocytopaenia (platelets <100 x10/L). In children, most cases are preceded by a viral infection. Cases of ITP in the setting of SARS-CoV-2 infection have been described.
View Article and Find Full Text PDFHereditary transthyretin amyloidosis presenting with spontaneous periorbital purpura: a case report.
Eur Heart J Case Rep
March 2023
Department of Advanced Heart Failure and Transplantation, Mayo Clinic, 4500 San Pablo Road S, Jacksonville, FL 32234, USA.
Background: Amyloidosis is a systemic disorder of abnormal protein folding and deposition resulting in a range of symptoms including neuropathy, heart failure, renal disease, and dermatologic findings. The two most common types of amyloidosis that affect the heart are transthyretin (ATTR) amyloidosis and light chain (AL) amyloidosis, which vary in clinical presentation. Skin findings such as periorbital purpura are considered more specific for AL amyloidosis.
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