Background And Purpose: Meningeal lymphatic vessels (MLVs) along the dural venous sinuses are suspected to be important in connecting the glymphatic and peripheral lymphatic system. Understanding the topography of MLVs may clarify the role of the glymphatic system in neurological diseases. The aim of this analysis was to use high resolution pre- and post-contrast FLAIR 7T MRI to identify and characterize the morphology of MLV in a cohort of healthy volunteers.
Materials And Methods: MRI examinations of seventeen healthy volunteers enrolled as controls in a larger 7T MRI study were reviewed. Pre- and post-contrast 3-D FLAIR subtractions and MP2RAGE sequences were spatially normalized and reviewed for signal intensity and enhancement patterns within putative MLVs along pre-determined dural and venous structures. Frequency of occurrence of MLVs at the above-described locations and patterns of their enhancement were analyzed.
Results: Putative MLVs are commonly located along the superior sagittal sinus (SSS) and cortical veins. A "fixed enhancement" signal pattern was more frequent at these locations (p<.05). The morphology of MLVs along the SSS qualitatively changes in an antero-posterior direction. Lack of signal was more frequent along the straight and transverse sinuses (p<.05).
Conclusion: Putative MLVs in healthy individuals are concentrated along the SSS and cortical veins. FLAIR signal and enhancement characteristics suggest these structures may transport proteinaceous fluid. Pathways connecting MLVs to cervical lymph nodes however remain unclear.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10981496 | PMC |
| http://dx.doi.org/10.1016/j.neurad.2023.03.002 | DOI Listing |
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Article Synopsis
- - Meningeal lymphatic vessels (mLVs) are vital for draining fluids and waste from the brain and moving immune cells to lymph nodes, helping coordinate the brain's immune response with the rest of the body
- - Dysfunction of mLVs, especially with aging and various CNS diseases, can lead to toxic buildup in the brain, worsening conditions like neurodegenerative diseases and tumors
- - The review discusses the anatomy and roles of mLVs in CNS health and disease, suggesting that targeting these vessels with drugs or therapies could improve treatment outcomes for CNS disorders
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