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Noise-induced ribbon synapse loss in the mouse basal cochlear region does not reduce inner hair cell exocytosis.
Front Cell Neurosci
January 2025
Experimental Otology Group, InnerEarLab, Department of Otolaryngology, University Medical Center Göttingen, Göttingen, Germany.
Noise-induced hearing loss is one of the most common forms of hearing loss in adults and also one of the most common occupational diseases. Extensive previous work has shown that the highly sensitive synapses of the inner hair cells (IHCs) may be the first target for irreparable damage and permanent loss in the noise-exposed cochlea, more precisely in the cochlear base. However, how such synaptic loss affects the synaptic physiology of the IHCs in this particularly vulnerable part of the cochlea has not yet been investigated.
View Article and Find Full Text PDFEcological risk assessment and response prediction caused by LUCC in the central Yunnan Province.
Sci Rep
January 2025
School of Economics, Yunnan University of Finance and Economics, Kunming, 650221, China.
With the acceleration of urbanization, unreasonable land use poses a serious threat to ecological security. However, there is still some space for improvement in the existing assessment of ecological risks (ERs) caused by land use/land cover change (LUCC). Therefore, this study takes the central Yunnan Province (CYP) as an example, and uses the Patch-Generating Land Use Simulation (PLUS) model and the Integrated Valuation of Ecosystem Services and Trade-offs (InVEST) model to simulate the land use/land cover (LULC) in different scenarios in the future, calculate the ecosystem services (ESs) from 2000 to 2020 and the next 20 years, as well as ERs of various types of ESs caused by LUCC.
View Article and Find Full Text PDFAn update on selective estrogen receptor modulator: repurposing and formulations.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Pharmaceutics & Pharmaceutical Technology, Shree S. K. Patel College of Pharmaceutical Education & Research, Ganpat University, Kherva, Gujarat, 384012, India.
The selective estrogen receptor modulator (SERM) raloxifene hydrochloride (RLH) is used extensively in the management and prevention of breast cancer and osteoporosis. Recent clinical studies show the repurposing of RLH in various diseases based on its structure and some clinical trials studies. Optimizing the clinical effectiveness of this important drug requires a thorough review of the formulation techniques, patent environment, and analytical procedures.
View Article and Find Full Text PDFTrends in ready-to-use portable electrochemical sensing devices for healthcare diagnosis.
Mikrochim Acta
January 2025
Department of Chemistry, Indian Institute of Technology Palakkad, Palakkad, Kerala, 678557, India.
Compared with previous decades, healthcare has emerged as a key global concern in light of the recurrent outbreak of pandemics. The initial stage in the provision of healthcare involves the process of diagnosis. Countries worldwide advocate for healthcare research due to its efficacy and capacity to assist diverse populations.
View Article and Find Full Text PDFRegistries in allergy: Structure, target groups, and key findings of allergy-focused registries in Germany.
Allergol Select
December 2024
Division of Allergy and Immunology, Department of Dermatology, Venerology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
In allergology, clinical registries fill knowledge gaps of epidemiology, mechanisms of allergic diseases, and real-world treatment outcomes. Considering the continuous rise of allergic diseases worldwide, registries become increasingly important for the optimization and harmonization of patient care. In the current review, we present four ongoing allergy-focused registries initiated in Germany.
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