A regioselective step-by-step CCl functionalization approach affords a novel family of CArTh'Th''H fullerene derivatives with promising antiviral properties.

We report a novel reaction of the recently discovered family of fullerene derivatives -CArTh' with thiophene derivatives Th''H yielding a previously unknown family of -CArTh'Th''H compounds with three different types of functional aromatic addends attached to the carbon cage. The discovered reaction paves a way to the synthesis of novel C fullerene derivatives with promising antioxidant and antiviral properties.