Objective: Long intergenic noncoding RNA 00632 (LINC00632) regulates nasal inflammation and CD4 T cell differentiation into T helper (Th) 2 cells in allergic rhinitis (AR). This study aimed to explore the relationship between LINC00632 and Th1/Th2 balance, and the clinical value of LINC00632 in AR patients.
Methods: In total, 120 AR patients, 20 non-atopic obstructive snoring patients as disease controls (DCs), and 20 healthy controls (HCs) were recruited. Their LINC00632 expressions in peripheral blood mononuclear cells were detected by RT-qPCR.
Results: LINC00632 expression was declined in AR patients compared with DCs and HCs (both ˂ 0.001). Moreover, LINC00632 could distinguish AR patients from DCs with an area under curve (AUC) of 0.795 (95% confidence interval [CI]: 0.701-0.889), and from HCs with an AUC of 0.895 (95%CI: 0.831-0.960). LINC00632 was positively related to Th1 cells ( = 0.037) and Th1/Th2 axis ( ˂ 0.001) in AR patients. In addition, LINC00632 was inversely associated with Th2 cells ( ˂ 0.001) and interleukin (IL)-4 ( = 0.010) in AR patients. Besides, LINC00632 was negatively related to rhinorrhea score ( = 0.019), itching score ( = 0.008), sneezing score ( = 0.004), and total nasal symptom score (TNSS) ( ˂ 0.001), but no correlation between LINC00632 and congestion score was observed ( = 0.093). During treatment, LINC00632 was elevated, while TNSS score was reduced (both ˂ 0.001). Furthermore, LINC00632 increment was associated with the reduction of TNSS score during the therapy ( = 0.005).
Conclusion: LINC00632 relates to milder Th1/Th2 imbalance, attenuated nasal symptoms, and better response during 4-week therapy in AR patients.
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