AI Article Synopsis
- Mob4 is a conserved protein important for cell division and neural development, part of the STRIPAK complex involved in key cellular processes.
- Despite its significance, the function of Mob4 in vertebrates is not well understood, with more clarity seen in Drosophila studies.
- Research on zebrafish reveals that reducing Mob4 during embryonic development restricts neuronal cell divisions but does not significantly impact cell death (apoptosis), indicating its role in neurodevelopment.
Article Abstract
Mob4 is an essential evolutionary conserved protein shown to play roles in cell division and neural development. Mob4 is a core component of the macromolecular STRIPAK complex involved in various critical cellular processes, from cell division to signal transduction pathways. However, Mob4 remains relatively poorly understood. Although the consequences of eliminating Mob4 function in Drosophila are described, its function in vertebrate development remains largely unknown. Here we show that knockdown and knockout of Mob4 during zebrafish embryogenesis limits neuronal cell divisions but has little effect on apoptosis, thus arguing a role for mob4 in neurodevelopment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006847 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.000762 | DOI Listing |
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