Objective: This study investigated the interaction of dyslipidemia and hyperuricemia on periodontitis in patients with type 2 diabetes mellitus (T2DM).
Methods: The clinical data of 220 patients with T2DM (diabetes group) treated in Tianjin Baodi Hospital from January 2019 to December 2021 were retrospectively analyzed. Another 200 healthy subjects in the same period were selected as the control group. The correlation of hyperuricemia and hyperlipidemia with diabetes was tested by the spearman correlation coefficient. Multivariate logistic regression was used to analyze the multiplicative interaction and additive interaction of dyslipidemia and hyperuricemia on periodontitis.
Results: Diabetes was positively correlated with hyperuricemia and hyperlipidemia (<0.05). Patients with dyslipidemia (OR = 8.107, 95% CI: 2.687-24.457) and hyperuricemia (OR = 2.940, 95% CI: 0.970-8.909) had a higher risk of periodontitis, but there was no multiplicative interaction effect of dyslipidemia and hyperuricemia on periodontitis (OR = 1.864, 95% CI: 0.256-13.545, >0.05). The risk of developing diabetes was higher in individuals with dyslipidemia and hypertension than in those without (OR = 2.887, 95% CI: 1.478-4.855). The evaluation indexes of the combined interaction effect relative excess risk due to interaction, interaction attribution percentage and synergy index were 0.902 (95% CI: 0.379-1.496), 0.273 (95% CI: 0.106-0.458) and 1.485 (95% CI: 0.978-2.165), respectively.
Conclusion: Dyslipidemia and hyperuricemia may have a synergistic effect on periodontitis in people with T2DM. Improving blood lipids and controlling blood uric acid may synergistically prevent periodontitis.
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View Article and Find Full Text PDFArticle Synopsis
- The study investigates the relationship between serum uric acid (SUA) levels and dyslipidaemia in patients with type 2 diabetes mellitus (T2DM) to find an optimal SUA level for lower dyslipidaemia risk.
- Researchers analyzed data from 1,036 T2DM inpatients and found that hyperuricaemia was significantly linked to a higher risk of dyslipidaemia and hypertriglyceridaemia.
- Results suggest that managing SUA levels could help decrease the risk of dyslipidaemia in T2DM patients, indicating the importance of SUA in triglyceride metabolism related to insulin resistance.
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