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Skin, gut, and sand metagenomic data on placebo-controlled sandbox biodiversity intervention study. | LitMetric

AI Article Synopsis

  • This article presents metagenomic data related to a study exploring the impact of diverse environmental microbes on children's immune health through a controlled trial involving sandbox sand at daycare centers.
  • In the intervention group, children were exposed to sand with a rich microbial community, while the placebo group played in visually similar but microbially poor sand.
  • High throughput sequencing of 16S rRNA showed significant changes in the skin microbiota of the intervention group over time, highlighting shifts in bacterial community composition, whereas no changes were observed in the placebo group.

Article Abstract

The metagenomic data presented in this article are related to the published research of "A Placebo-controlled double-blinded test of the biodiversity hypothesis of immune-mediated diseases: Environmental microbial diversity elicits changes in cytokines and increase in T regulatory cells in young children" This database contains 16S ribosomal RNA (rRNA) metagenomics of sandbox sand and skin and gut microbiota of children in the intervention and placebo daycares. In intervention daycares, children aged 3-5 years were exposed to playground sand enriched with microbially diverse soil. In placebo daycares, children were exposed to visually similar as in intervention daycares, but microbially poor sand colored with peat. Sand, skin and gut metagenomics were analyzed at baseline and after 14 and 28 days of intervention by high throughput sequencing of bacterial 16S rRNA gene on the Illumina MiSeq platform. This dataset shows how skin bacterial community composition, including classes Gammaproteobacteria and Bacilli, changed, and how the relative abundance of over 30 bacterial genera shifted on the skin of children in the intervention treatment, while no shifts occurred in the placebo group.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10006422PMC
http://dx.doi.org/10.1016/j.dib.2023.109003DOI Listing

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